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公开(公告)号：EP0724576A1
公开(公告)日：1996-08-07
申请号：EP94929152.0
申请日：1994-09-15
申请人： CYTOGEN CORPORATION
CPC分类号： C07F9/6524 , C07F9/025 , C07F9/3817
摘要： A process for the purification of aminophosphonic acids under non-alkaline conditions is described. In particular, aminophosphonic acids are slurred in neutral or acidic water, heated to reflux, cooled and then filtered. Product purities approaching 100 % are thus obtained.
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公开(公告)号：EP0635001B1
公开(公告)日：1997-08-20
申请号：EP93911594.5
申请日：1993-04-08
申请人： CYTOGEN CORPORATION
IPC分类号： C07C337/06 , C07C335/22 , C07D207/44 , C07D213/71
CPC分类号： C07D207/452 , A61K47/50 , A61K51/082 , A61K51/088 , A61K51/1093 , A61K2121/00 , A61K2123/00 , C07C335/22 , C07C337/06 , C07D213/71
摘要： This invention relates to chelating agents of formula (I), in which L is a linker; D is an alkyl backbone, cyclic alkyl backbone or aryl backbone group substituted with the NHCSNHR groups: and R is hydrogen or a substituent of general formula (1) in which a = 0 or 1; b = 0-10; c = 0 or 1; if c = 1, Y = S, O or H2; d = 0-2; e = 0-10; and Z = H, N+(R')3X-, SO3H, CO2H, OH, H2PO3; in which X- is a counterion such as a halide or an acid anion and R' is a C¿1? to C4 lower alkyl, useful for coupling metal ions to biologically active molecules. In particular, substantial thioureas for chelating metals such as technetium are provided that can be conjugated to a targeting molecule such as an antibody, a peptide or a protein.
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公开(公告)号：EP0724576B1
公开(公告)日：2002-03-20
申请号：EP94929152.0
申请日：1994-09-15
申请人： CYTOGEN CORPORATION
IPC分类号： C07F9/38 , C07F9/6524
CPC分类号： C07F9/6524 , C07F9/025 , C07F9/3817
摘要： A process for the purification of aminophosphonic acids under non-alkaline conditions is described. In particular, aminophosphonic acids are slurred in neutral or acidic water, heated to reflux, cooled and then filtered. Product purities approaching 100 % are thus obtained.
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4.发明公开
公开(公告)号：EP1019071A2
公开(公告)日：2000-07-19
申请号：EP98922385.4
申请日：1998-05-15
发明人： ALVAREZ, Vernon, L. , O'MAHONY, Daniel, J. , LAMBKIN, Imelda, J. , PATTERSON, Catherine, A. , SINGLETON, Judith , BELINKA, Benjamin, A., Jr. , CARTER, John, M. , CAGNEY, Gerard, M.
CPC分类号： A61K38/09 , A61K9/5153 , A61K38/28 , A61K47/62 , A61K47/6937 , B82Y5/00 , C07K1/047 , C07K5/1013 , C07K5/1016 , C07K14/001 , C07K14/705 , C07K2319/00
摘要： This invention relates to proteins (e.g., peptides) that are capable of facilitating transport of an active agent through a human or animal gastro-intestinal tissue, and derivatives (e.g., fragments) and analogs thereof, and nucleotide sequences coding for said proteins and derivatives. The proteins of the invention have use in facilitating transport of active agents from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. Thus, for example, by binding (covalently or noncovalently) a protein of the invention to an orally administered drug, the drug can be targeted to specific receptor sites or transport pathways which are known to operate in the human gastro-intestinal tract, thus facilitating its absorption into the systemic system.
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公开(公告)号：EP0635001A1
公开(公告)日：1995-01-25
申请号：EP93911594.0
申请日：1993-04-08
申请人： CYTOGEN CORPORATION
CPC分类号： C07D207/452 , A61K47/50 , A61K51/082 , A61K51/088 , A61K51/1093 , A61K2121/00 , A61K2123/00 , C07C335/22 , C07C337/06 , C07D213/71
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