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公开(公告)号：EP0348261A1
公开(公告)日：1989-12-27
申请号：EP89401557.7
申请日：1989-06-06
申请人： CYTOGEN CORPORATION
IPC分类号： C07C243/00 , C07C215/00 , C07C217/00 , C07B59/00 , A61K49/02 , A61K43/00 , C07K15/00
CPC分类号： A61K51/1051 , A61K51/1063 , A61K2121/00
摘要： Radiohalogenated compounds which are useful as intermediates for preparing radiohalogenated antibody conjugates in which the radiohalogenated compound is site specifically attached to an oxidized carbohydrate moiety of an antibody or antibody fragment are disclosed. Methods for making the compounds and the antibody conjugates as well as methods of use of the same are also disclosed.
摘要翻译： 可用作制备放射性卤化抗体缀合物的中间体的放射性卤化化合物，其中放射性卤化化合物特异性连接于抗体或抗体片段的氧化碳水化合物部分。 还公开了制备化合物和抗体缀合物的方法及其使用方法。
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公开(公告)号：EP0175617A3
公开(公告)日：1988-06-15
申请号：EP85401776
申请日：1985-09-13
申请人： CYTOGEN CORPORATION
发明人： Goers, John Walter , Lee, Chyi , Siegel, Richard Charles , McKearn, Thomas Joseph , King, Hurley Dalton , Coughlin, Daniel James , Rodwell, John Dennis , Alvarez, Vernon Leon
IPC分类号： A61K39/395
CPC分类号： A61K51/1093 , A61K41/0042 , A61K41/0057 , A61K41/0071 , A61K51/10 , A61K2121/00
摘要： This invention relates to antibody-therapeutic agent conjugates having a therapeutic agent covalently attached to an antibody or antibody fragment. Also described are methods for intermediates in the preparation of antibody conjugates. Therapeutic in vivo methods utilizing such antibody-therapeutic agent conjugates are described. Additionally novel photosensitizers suitable for use in preparing antibody-therapeutic agents are also described.
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公开(公告)号：EP0175617A2
公开(公告)日：1986-03-26
申请号：EP85401776.1
申请日：1985-09-13
申请人： CYTOGEN CORPORATION
发明人： Goers, John Walter , Lee, Chyi , Siegel, Richard Charles , McKearn, Thomas Joseph , King, Hurley Dalton , Coughlin, Daniel James , Rodwell, John Dennis , Alvarez, Vernon Leon
IPC分类号： A61K39/395
CPC分类号： A61K51/1093 , A61K41/0042 , A61K41/0057 , A61K41/0071 , A61K51/10 , A61K2121/00
摘要： This invention relates to antibody-therapeutic agent conjugates having a therapeutic agent covalently attached to an antibody or antibody fragment. Also described are methods for intermediates in the preparation of antibody conjugates. Therapeutic in vivo methods utilizing such antibody-therapeutic agent conjugates are described. Additionally novel photosensitizers suitable for use in preparing antibody-therapeutic agents are also described.
摘要翻译： 本发明涉及具有共价连接于抗体或抗体片段的治疗剂的抗体治疗剂缀合物。 还描述了制备抗体缀合物的中间体的方法。 描述了利用这种抗体治疗剂缀合物的治疗性体内方法。 还描述了适用于制备抗体治疗剂的新型光敏剂。
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公开(公告)号：EP0348261B1
公开(公告)日：1993-12-15
申请号：EP89401557.7
申请日：1989-06-06
申请人： CYTOGEN CORPORATION
IPC分类号： C07C243/00 , C07C215/00 , C07C217/00 , C07B59/00 , A61K49/02 , A61K43/00 , C07K15/00
CPC分类号： A61K51/1051 , A61K51/1063 , A61K2121/00
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公开(公告)号：EP0175617B1
公开(公告)日：1991-10-30
申请号：EP85401776.1
申请日：1985-09-13
申请人： CYTOGEN CORPORATION
发明人： Goers, John Walter , Lee, Chyi , Siegel, Richard Charles , McKearn, Thomas Joseph , King, Hurley Dalton , Coughlin, Daniel James , Rodwell, John Dennis , Alvarez, Vernon Leon
IPC分类号： A61K39/395
CPC分类号： A61K51/1093 , A61K41/0042 , A61K41/0057 , A61K41/0071 , A61K51/10 , A61K2121/00
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