公开(公告)号：EP2773618A1

公开(公告)日：2014-09-10

申请号：EP12839179.4

申请日：2012-11-02

申请人： Cadila Healthcare Limited

发明人： DWIVEDI, Shriprakash Dhar ,  PATEL, Vipul Kantibhai ,  PATEL, Mahesh Shankarbhai ,  SHAH, Niraj Shyamlal ,  PRASAD, Ashok ,  JAIN, Kuldeep Natwarlal

IPC分类号： C07D213/61

CPC分类号： C07D213/61

摘要： The invention relates to an improved process for the preparation of etoricoxib and polymorphs thereof. In particular, the, invention relates to a process for the preparation of stable crystalline Form-I of etoricoxib. Further, the invention also relates to a process for the preparation of amorphous form of etoricoxib. The invention also relates to pharmaceutical compositions that include the stable crystalline Form-I of etoricoxib.

摘要翻译： 本发明涉及一种改进的依托昔布及其多晶型物的制备方法。 特别地，本发明涉及一种制备艾托考昔的稳定结晶形式I的方法。 此外，本发明还涉及制备无定形形式的依托昔昔的方法。 本发明还涉及药物组合物，其包括稳定的依托昔昔的晶型I。