公开(公告)号：EP2780327A1

公开(公告)日：2014-09-24

申请号：EP12839184.4

申请日：2012-11-12

申请人： Cadila Healthcare Limited

发明人： DWIVEDI, Shriprakash Dhar ,  PRASAD, Ashok ,  SHARMA, Mukul Hariprasad ,  SHARMA, Piyush Rajendra ,  PARIHAR, Jaiprakash Ajitsingh

IPC分类号： C07D223/16 ,  A61K31/55 ,  A61P9/06

CPC分类号： C07D223/16 ,  B65B7/02 ,  B65B31/00 ,  B65B61/20 ,  B65D31/02 ,  B65D31/04 ,  B65D81/266 ,  C07B2200/13 ,  C30B7/02 ,  C30B29/54 ,  Y10T428/2982

摘要： A storage stable crystalline Form II of ivabradine hydrochloride having characteristic X-ray powder diffraction peaks at about 15.50°, 18.02°, 19.00°, 19.80°, 22.42°, 24.16°, and 25.46°±0.2° (2¸); comprising a packaging which includes placing crystalline ivabradine hydrochloride in a non-permeable bag; placing the non-permeable bag in polyethylene bag, optionally containing oxygen busters and sealing it; placing the polyethylene bag in a triple laminated bag, optionally containing oxygen busters and sealing it; placing the triple laminated bag inside a high density polyethylene (HDPE) container and sealing it.

摘要翻译： 公开了伊伐布雷定盐酸盐的稳定结晶形式II和稳定结晶形式III及其制备方法。

公开(公告)号：EP2773618A1

公开(公告)日：2014-09-10

申请号：EP12839179.4

申请日：2012-11-02

申请人： Cadila Healthcare Limited

发明人： DWIVEDI, Shriprakash Dhar ,  PATEL, Vipul Kantibhai ,  PATEL, Mahesh Shankarbhai ,  SHAH, Niraj Shyamlal ,  PRASAD, Ashok ,  JAIN, Kuldeep Natwarlal

IPC分类号： C07D213/61

CPC分类号： C07D213/61

摘要： The invention relates to an improved process for the preparation of etoricoxib and polymorphs thereof. In particular, the, invention relates to a process for the preparation of stable crystalline Form-I of etoricoxib. Further, the invention also relates to a process for the preparation of amorphous form of etoricoxib. The invention also relates to pharmaceutical compositions that include the stable crystalline Form-I of etoricoxib.

摘要翻译： 本发明涉及一种改进的依托昔布及其多晶型物的制备方法。 特别地，本发明涉及一种制备艾托考昔的稳定结晶形式I的方法。 此外，本发明还涉及制备无定形形式的依托昔昔的方法。 本发明还涉及药物组合物，其包括稳定的依托昔昔的晶型I。

公开(公告)号：EP2097383A2

公开(公告)日：2009-09-09

申请号：EP07870531.6

申请日：2007-11-30

申请人： Cadila Healthcare Limited

发明人： DWIVEDI, Shriprakash Dhar ,  KUMAR, Rajiv ,  PATEL, Sunil Tribhovandas ,  SHAH, Alpeshkumar Parvin Chandra

IPC分类号： C07D223/16 ,  C07C217/56

CPC分类号： C07D223/16 ,  C07C217/58 ,  C07C2602/06

摘要： The present invention provides a process for preparing Ivabradine of formula (I) or its pharmaceutically acceptable salts, solvates, hydrate thereof, by reacting 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N- methylpropan-1 -amine of formula (IV), with 7,8-Dimethoxy-l,3,4,5-tetrahydro-benzo[d]azepin-2-one of formula (V) or its alkaline salt, Formula (V): in presence of base in suitable solvent to provide Ivabradine of formula (I), which can be subsequently converted to its pharmaceutically acceptable salts, solvate or hydrate thereof.

公开(公告)号：EP3156399A1

公开(公告)日：2017-04-19

申请号：EP16184235.6

申请日：2012-11-12

申请人： Cadila Healthcare Limited

发明人： DWIVEDI, Shriprakash Dhar ,  PRASAD, Ashok ,  SHARMA, Mukul Hariprasad ,  SHARMA, Piyush Rajendra ,  PARIHAR, Jaiprakash Ajitsingh

IPC分类号： C07D223/16 ,  A61K31/55 ,  A61P9/06 ,  B65B31/00

CPC分类号： C07D223/16 ,  B65B7/02 ,  B65B31/00 ,  B65B61/20 ,  B65D31/02 ,  B65D31/04 ,  B65D81/266 ,  C07B2200/13 ,  C30B7/02 ,  C30B29/54 ,  Y10T428/2982

摘要： A storage stable crystalline Form II of ivabradine hydrochloride having characteristic X-ray powder diffraction peaks at about 15.50°, 18.02°, 19.00°, 19.80°, 22.42°, 24.16°, and 25.46°±0.2° (2θ); comprising a packaging which includes placing crystalline ivabradine hydrochloride in a non-permeable bag; placing the non-permeable bag in polyethylene bag, optionally containing oxygen busters and sealing it; placing the polyethylene bag in a triple laminated bag, optionally containing oxygen busters and sealing it; placing the triple laminated bag inside a high density polyethylene (HDPE) container and sealing it.

摘要翻译： 在约15.50°，18.02°，19.00°，19.80°，22.42°，24.16°和25.46°±0.2°（2θ）处具有特征X射线粉末衍射峰的储存稳定的伊伐布雷定盐酸盐的晶型II; 包括一种包装，该包装包括将结晶伊伐布雷定盐酸盐放入不可渗透袋中; 将不可渗透的袋放入聚乙烯袋中，可选地包含氧气栓并将其密封; 将聚乙烯袋放入三层层压袋中，任选地包含氧气阻隔器并将其密封; 将三层层压袋放入高密度聚乙烯（HDPE）容器内并密封。

公开(公告)号：EP2097383B1

公开(公告)日：2012-02-08

申请号：EP07870531.6

申请日：2007-11-30

申请人： Cadila Healthcare Limited

发明人： DWIVEDI, Shriprakash Dhar ,  KUMAR, Rajiv ,  PATEL, Sunil Tribhovandas ,  SHAH, Alpeshkumar Parvin Chandra

IPC分类号： C07D223/16 ,  C07C217/56

CPC分类号： C07D223/16 ,  C07C217/58 ,  C07C2602/06

摘要： The present invention provides a process for preparing Ivabradine of formula (I) or its pharmaceutically acceptable salts, solvates, hydrate thereof, by reacting 3-chloro-N-{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}-N- methylpropan-1 -amine of formula (IV), with 7,8-Dimethoxy-l,3,4,5-tetrahydro-benzo[d]azepin-2-one of formula (V) or its alkaline salt, Formula (V): in presence of base in suitable solvent to provide Ivabradine of formula (I), which can be subsequently converted to its pharmaceutically acceptable salts, solvate or hydrate thereof.

摘要翻译： 本发明涉及结晶伊伐布雷定盐酸盐形式I及其制备方法。

公开(公告)号：EP3004053A2

公开(公告)日：2016-04-13

申请号：EP14767148.1

申请日：2014-05-30

申请人： Cadila Healthcare Limited

发明人： DWIVEDI, Shriprakash Dhar ,  SINGH, Ramesh Chandra ,  CHAVDA, Rajendra Gokalbhai ,  PATEL, Jagdish Maganlal ,  PAL, Daya Ram ,  RAVAL, Jigar Mukundhai ,  SHARMA, Mukul Hariprasad ,  GANGWAR, Pranav Jitendra ,  PATIL, Sachin Ashokrao ,  PATEL, Vikas ,  TRIPATHI, Vishwadeepak Rama Patil

IPC分类号： C07D207/325 ,  A61K31/40 ,  A61P3/00

CPC分类号： C07D207/333 ,  A61K31/402 ,  C07D207/32 ,  C07D207/325

摘要： The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also provides a process for the preparation of saroglitazar. The invention further provides intermediates as well process for preparation thereof.

摘要翻译： 本发明提供具有降血脂低胆固醇活性的吡咯。 本发明提供了saroglitazar及其药学上可接受的盐，水合物，溶剂合物，多晶型物或其中间体。 本发明还提供了制备西格列塔的方法。 本发明还提供中间体及其制备方法。