公开(公告)号：EP3317323A1

公开(公告)日：2018-05-09

申请号：EP16818439.8

申请日：2016-06-13

申请人： California Institute of Technology

发明人： DAVIS, Mark, E. ,  PAN, Dorothy

IPC分类号： C08G65/34 ,  C08G65/333 ,  C08G63/06 ,  C08J3/12 ,  C08J5/00 ,  C08J3/075 ,  C08L67/04 ,  C08L71/02

CPC分类号： C08G81/00 ,  A61K9/5031 ,  A61K47/34 ,  C08G69/40 ,  C08G73/028 ,  C08G79/08 ,  C08J3/12

摘要： wherein is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage.

公开(公告)号：EP3795609A1

公开(公告)日：2021-03-24

申请号：EP20186381.8

申请日：2016-06-13

申请人： California Institute of Technology

发明人： DAVIS, Mark E. ,  PAN, Dorothy

IPC分类号： C08G65/34 ,  C08G65/333 ,  C08G63/06 ,  C08J3/12 ,  C08J5/00 ,  C08J3/075 ,  C08L67/04 ,  C08L71/02

摘要： The present disclosure is directed to polymer and polymer conjugate-based nanoparticle delivery systems for delivering biological agents, and methods of making and using these compositions. Certain embodiments of the present disclosure provide a nanoparticle comprising a polymer comprising alternating charged and uncharged segments comprising one or more of the following structural units of Formula (I), Formula (II) or Formula (III):



wherein A is an uncharged segment comprising polyalkylene glycol; and B is a cationically charged segment comprising at least one polyhydroxy linkage comprising at least one pair of vicinal diols.