专利检索 ap:("California Institute of Technology" OR "Cleave Biosciences, Inc. (Cleave)" OR "THE UNIVERSITY OF KANSAS") AND inv:"GERRITZ, Samuel, W." 第 1 页

1.

发明公开
METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE 审中-公开
标题翻译：方法和组合物用于抑制蛋白VALOSINHALTIGEN

公开(公告)号：EP2566480A2

公开(公告)日：2013-03-13

申请号：EP11778469.4

申请日：2011-05-06

申请人： California Institute of Technology , Cleave Biosciences, Inc. (Cleave) , THE UNIVERSITY OF KANSAS

发明人： DESHAIES, Raymond, J. , CHOU, Tsui-fen , SCHOENEN, Frank, J. , LI, Kelin , FRANKOWSKI, Kevin, J. , AUBE, Jeffrey , GERRITZ, Samuel, W. , ZHOU, Han-jie

IPC分类号： A61K31/517 , A61K31/53 , A61K31/4184 , A61P35/00

CPC分类号： A61K31/517 , A61K31/4184 , A61K31/53 , A61K31/538 , C12Q1/42 , C12Q1/485 , G01N2500/02

摘要： Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof