公开(公告)号：EP1175445A1

公开(公告)日：2002-01-30

申请号：EP00927483.8

申请日：2000-05-02

申请人： Cambridge Antibody Technology Limited

发明人： THOMPSON, Julia, Elizabeth ,  LENNARD, Simon, Nicholas ,  WILTON, Alison, Jane ,  BRADDOCK, Peta, Sally, Helena ,  DU FOU, Sarah, Leila ,  MCCAFFERTY, John, Gerald ,  CONROY, Louise, Anne ,  TEMPEST, Philip, Ronald

IPC分类号： C07K16/22 ,  A61K39/395 ,  G01N33/577 ,  A61P35/00 ,  A61P13/12 ,  A61P27/02 ,  A61P37/00 ,  A61P11/06

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622

摘要： The invention provides specific binding members, for example in the form of antibody variable domains, based on the CDR3 sequences of the antibody VH regions of SL15 (SEQ ID NO:4) and JT182 (SEQ ID NO:10). The antibodies have strong neutralising activity for TGFβ1 and are useful in treating conditions associated with excess TGFβ1 activity, such as fibrosis, immune responses and tumour progression.

公开(公告)号：EP1175445B1

公开(公告)日：2004-07-28

申请号：EP00927483.8

申请日：2000-05-02

申请人： Cambridge Antibody Technology Limited

发明人： THOMPSON, Julia, Elizabeth ,  LENNARD, Simon, Nicholas ,  WILTON, Alison, Jane ,  BRADDOCK, Peta, Sally, Helena ,  DU FOU, Sarah, Leila ,  MCCAFFERTY, John, Gerald ,  CONROY, Louise, Anne ,  TEMPEST, Philip, Ronald

IPC分类号： C07K16/22 ,  A61K39/395 ,  G01N33/577 ,  A61P35/00 ,  A61P13/12 ,  A61P27/02 ,  A61P37/00 ,  A61P11/06

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622