公开(公告)号：EP3167000A1

公开(公告)日：2017-05-17

申请号：EP15818380.6

申请日：2015-07-08

申请人： Cambridge Polymer Group, Inc.

发明人： BRAITHWAITE, Gavin ,  SVIRKIN, Yuri

IPC分类号： C08K5/41

CPC分类号： C08J3/075 ,  A61K31/00 ,  A61K31/795 ,  A61K47/32 ,  C08J2329/04

摘要： A method of forming thiolated poly(vinyl alcohol) hydrogels including reacting, in the presence of an acid, compounds containing a thiol functional group and a hydroxyl reactive group with one or more hydroxyl groups of poly(vinyl alcohol) via said hydroxyl reactive group, thereby forming thiolated poly(vinyl alcohol). The method further including reacting the thiol functional group of said compounds with a thiol reactive group of a crosslinker, thereby forming a hydrogel.

摘要翻译： 一种形成硫醇化聚乙烯醇水凝胶的方法，包括在酸的存在下使含有硫醇官能团和羟基反应性基团的化合物与聚乙烯醇的一个或多个羟基通过所述羟基反应性基团反应， 从而形成硫醇化聚乙烯醇。 该方法进一步包括使所述化合物的硫醇官能团与交联剂的硫醇反应性基团反应，由此形成水凝胶。