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公开(公告)号：EP3167000A1
公开(公告)日：2017-05-17
申请号：EP15818380.6
申请日：2015-07-08
Applicant: Cambridge Polymer Group, Inc.
Inventor： BRAITHWAITE, Gavin , SVIRKIN, Yuri
IPC: C08K5/41
CPC classification number: C08J3/075 , A61K31/00 , A61K31/795 , A61K47/32 , C08J2329/04
Abstract: A method of forming thiolated poly(vinyl alcohol) hydrogels including reacting, in the presence of an acid, compounds containing a thiol functional group and a hydroxyl reactive group with one or more hydroxyl groups of poly(vinyl alcohol) via said hydroxyl reactive group, thereby forming thiolated poly(vinyl alcohol). The method further including reacting the thiol functional group of said compounds with a thiol reactive group of a crosslinker, thereby forming a hydrogel.
Abstract translation: 一种形成硫醇化聚乙烯醇水凝胶的方法，包括在酸的存在下使含有硫醇官能团和羟基反应性基团的化合物与聚乙烯醇的一个或多个羟基通过所述羟基反应性基团反应， 从而形成硫醇化聚乙烯醇。 该方法进一步包括使所述化合物的硫醇官能团与交联剂的硫醇反应性基团反应，由此形成水凝胶。
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公开(公告)号：EP2125906A4
公开(公告)日：2014-07-16
申请号：EP08731238
申请日：2008-03-03
Applicant: GEN HOSPITAL CORP , CAMBRIDGE POLYMER GROUP INC
Inventor： MURATOGLU ORHUN K , SPIEGELBERG STEPHEN H
CPC classification number: A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L2430/02 , C08J3/226 , C08J3/247 , C08J3/28 , C08J2323/06 , C08J2423/00 , C08K5/1545 , C08K2201/012 , C08L23/06 , C08L2666/02 , C08K5/005
Abstract: The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
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3.发明公开Methods for making oxidation-resistant cross-linked polymeric materials 审中-公开Verfahren zur Herstellung vonoxidationsbeständigemvernetztem Polymermaterial
公开(公告)号：EP2464195A1
公开(公告)日：2012-06-13
申请号：EP12150677.8
申请日：2008-01-25
Inventor： Oral, Ebru , Muratoglu, Orhun , Kopesky, Edward
CPC classification number: A61L27/505 , A61L27/16 , B29C43/003 , B29C43/18 , B29C71/04 , B29K2023/0683 , B29K2105/20 , B29K2995/0056 , B29L2031/753 , C08F10/02 , C08F110/02 , C08J3/24 , C08J3/28 , C08J2323/06 , C08K5/1545 , C08K2201/012 , C08F2/46 , C08F2500/01
Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
Abstract translation: 本发明涉及制备交联抗氧化聚合物材料的方法，并且防止或最小化来自含抗氧化剂的聚合物材料的抗氧化剂的体内洗脱。 本发明还提供了掺杂具有交联和抗氧化分布的空间控制的聚合材料的方法，例如维生素E（± - 生育酚），以及用于提取/洗脱抗氧化剂的方法，例如维生素E（±生育酚 ），来自含抗氧化剂的聚合物材料的表面区域，以及与其一起使用的材料。
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公开(公告)号：EP2110002B1
公开(公告)日：2012-04-25
申请号：EP08728244.8
申请日：2008-01-25
Inventor： MURATOGLU, Orhun, K. , KOPESKY, Edward, T. , ORAL, Ebru
CPC classification number: A61L27/505 , A61L27/16 , B29C43/003 , B29C43/18 , B29C71/04 , B29K2023/0683 , B29K2105/20 , B29K2995/0056 , B29L2031/753 , C08F10/02 , C08F110/02 , C08J3/24 , C08J3/28 , C08J2323/06 , C08K5/1545 , C08K2201/012 , C08F2/46 , C08F2500/01
Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (±-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (±-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
Abstract translation: 本发明涉及制备交联的抗氧化聚合物材料和防止或最小化抗氧化剂从含抗氧化剂的聚合物材料体内洗脱的方法。 本发明还提供了掺杂空间控制交联和抗氧化剂分布的聚合物材料的方法，例如维生素E（α-生育酚），以及抗氧化剂的提取/洗脱方法，例如维生素E（α-生育酚 ）与含抗氧化剂的聚合物材料的表面区域以及与其一起使用的材料。
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5.发明公开METHODS FOR MAKING OXIDATION RESISTANT POLYMERIC MATERIAL 有权VERFAHREN ZUR HERSTELLUNG VONOXIDATIONSBESTÄNDIGEMPOLYMERMATERIAL
公开(公告)号：EP1750614A4
公开(公告)日：2011-10-26
申请号：EP05750134
申请日：2005-05-10
Applicant: GEN HOSPITAL CORP , CAMBRIDGE POLYMER GROUP INC
Inventor： MURATOGLU ORHUN K , SPIEGELBERG STEPHEN H
CPC classification number: A61L27/16 , A61L27/505 , C08L23/06 , C08L23/10 , C08L27/06 , C08L67/00 , C08L77/00 , C08L2312/06
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Patent Agency Ranking
公开(公告)号：EP1596755A4
公开(公告)日：2011-03-16
申请号：EP04702484
申请日：2004-01-15
Applicant: MASSACHUSETTS GEN HOSPITAL , CAMBRIDGE POLYMER GROUP INC
Inventor： MURATOGLU ORHUN K , SPIEGELBERG STEPHEN H
CPC classification number: B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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公开(公告)号：EP1888135A1
公开(公告)日：2008-02-20
申请号：EP05800222.1
申请日：2005-09-27
Inventor： MURATOGLU, Orhun K. , CHOI, Jeeyoung , BODUGOZ-SENTURK, H., Massachusetts Gen. Hospital , BRAITHWAITE, Gavin J.C. , SPIEGELBERG, Stephen H.
CPC classification number: C08F6/10 , A61F2/30756 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2002/30754 , A61L27/52 , C08J3/075 , C08J2329/04 , C08L29/04 , C08L71/02 , C08L2666/14
Abstract: The invention provides fabricated tough hydrogels, hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the tough hydrogels, or the hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making crosslinked tough hydrogels, and crosslinked tough hydrogel-containing compositions also are disclosed herein.
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公开(公告)号：EP1596755B1
公开(公告)日：2016-10-12
申请号：EP04702484.9
申请日：2004-01-15
Inventor： MURATOGLU, Orhun K. , SPIEGELBERG, Stephen H.
IPC: A61L27/16 , A61L27/50 , B29C35/08 , B29C43/00 , C08K5/1545 , C08L23/06 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08J3/28 , C08K5/00
CPC classification number: B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
Abstract: The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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公开(公告)号：EP2110002A4
公开(公告)日：2010-03-03
申请号：EP08728244
申请日：2008-01-25
Applicant: GEN HOSPITAL CORP , CAMBRIDGE POLYMER GROUP INC
Inventor： MURATOGLU ORHUN K , KOPESKY EDWARD T , ORAL EBRU
CPC classification number: A61L27/505 , A61L27/16 , B29C43/003 , B29C43/18 , B29C71/04 , B29K2023/0683 , B29K2105/20 , B29K2995/0056 , B29L2031/753 , C08F10/02 , C08F110/02 , C08J3/24 , C08J3/28 , C08J2323/06 , C08K5/1545 , C08K2201/012 , C08F2/46 , C08F2500/01
Abstract: The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (±-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (±-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
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公开(公告)号：EP1713851A2
公开(公告)日：2006-10-25
申请号：EP05751023.2
申请日：2005-02-04
Applicant: Cambridge Polymer Group, Inc.
Inventor： RUBERTI, Jeffrey, W. , BRAITHWAITE, Gavin J.C.
IPC: C08J3/075 , A61L27/16 , C08F283/01 , A61L15/60 , A61L27/52
CPC classification number: A61L27/26 , A61L27/16 , A61L27/52 , C08J3/075 , C08J2329/04 , C08L29/04 , C08L71/02
Abstract: In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hydrogel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including a dispenser and single use containers housing components that form the vinyl polymer hydrogel.
Abstract translation: 在优选的实施方案中，本发明提供了可控地制备具有所需物理性质的乙烯基聚合物水凝胶而无化学交联或辐射的方法。 通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂复合物中提供的活性成分来调节凝胶化过程。 根据优选实施方案，制造乙烯基聚合物水凝胶的方法包括以下步骤：提供包含溶解于第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热至高于乙烯基聚合物物理缔合点熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 诱导乙烯基聚合物溶液和胶凝剂的混合物的胶凝; 并控制凝胶化速率以形成粘弹性溶液，其中可操作性保持预定时间，由此制造具有所需物理性质的乙烯基聚合物水凝胶。 在进一步优选的实施方案中，本发明提供通过控制粘弹性溶液的凝胶化而生产的物理交联水凝胶，其中可操作性保持预定时间。 另一方面，本发明提供用于修复椎间盘或铰接接头的试剂盒，其包括分配器和形成乙烯基聚合物水凝胶的单次使用容器外壳部件。
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