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公开(公告)号：EP2781913B1
公开(公告)日：2017-12-13
申请号：EP14161288.7
申请日：2008-09-11
IPC分类号： G01N27/00 , B01D59/44 , G01N33/68 , G01N33/574
CPC分类号： G01N33/6848 , G01N33/57423 , G01N33/6893 , G01N2500/00 , G01N2800/12 , G01N2800/122
摘要： A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known two have non-small cell lung cancers and asthma, as diagnosed by a physician, Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identity of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
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公开(公告)号：EP3444359A1
公开(公告)日：2019-02-20
申请号：EP18194795.3
申请日：2010-03-12
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/574 , G01N33/68
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
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公开(公告)号：EP2781913A3
公开(公告)日：2014-10-15
申请号：EP14161288.7
申请日：2008-09-11
IPC分类号： G01N27/00 , B01D59/44 , G01N33/68 , G01N33/574
CPC分类号： G01N33/6848 , G01N33/57423 , G01N33/6893 , G01N2500/00 , G01N2800/12 , G01N2800/122
摘要： A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known two have non-small cell lung cancers and asthma, as diagnosed by a physician, Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identity of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
摘要翻译： 如在医生诊断的那样，鉴定存在于人血清中存在于正常个体和已知两个患者之间的差异表达的蛋白质的方法具有非小细胞肺癌和哮喘。来自每个群体的人血清样品用胰蛋白酶或任何其他合适的 内切蛋白酶并使用液相色谱电喷雾质谱仪进行分析。 比较来自每个群体的质谱数据以确定具有在正常，哮喘和肺癌群体之间显着差异表达的表达强度的蛋白质。 发现11种蛋白质具有在群体之间显着差异表达的表达强度。 最后，通过将质谱数据与具有已知蛋白质质谱数据库的已知数据库进行比较，获得11种蛋白质的身份。
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公开(公告)号：EP3257953B1
公开(公告)日：2018-09-26
申请号：EP17179032.2
申请日：2010-03-12
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57423 , G01N33/6893 , G01N2800/12
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
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5.发明公开METHODS OF IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF LUNG DISEASES AND KITS THEREOF INCLUDING GENDER-BASED DISEASE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY 审中-公开鉴别，评估，预防和治疗肺病及其套件，包括基于性别的疾病识别，评估，预防和治疗
公开(公告)号：EP3257953A1
公开(公告)日：2017-12-20
申请号：EP17179032.2
申请日：2010-03-12
IPC分类号： C12Q1/68 , C12N15/12 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57423 , G01N33/6893 , G01N2800/12
摘要： The invention provides biomarkers and combinations of biomarkers useful in diagnosing lung diseases such as non-small cell lung cancer or reactive airway disease. The invention also provides methods of differentiating lung disease, methods of monitoring therapy, and methods of predicting a subject's response to therapeutic intervention based on the extent of expression of the biomarkers and combinations of biomarkers. Kits comprising agents for detecting the biomarkers and combination of biomarkers are also provided.
摘要翻译： 本发明提供了用于诊断肺病例如非小细胞肺癌或反应性气道疾病的生物标志物和生物标志物的组合。 本发明还提供了基于生物标志物和生物标志物组合的表达程度，区分肺部疾病的方法，监测治疗方法以及预测受试者对治疗性干预的反应的方法。 还提供了包含用于检测生物标志物和生物标志物组合的试剂盒。
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6.发明公开
公开(公告)号：EP2781913A2
公开(公告)日：2014-09-24
申请号：EP14161288.7
申请日：2008-09-11
CPC分类号： G01N33/6848 , G01N33/57423 , G01N33/6893 , G01N2500/00 , G01N2800/12 , G01N2800/122
摘要： A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known two have non-small cell lung cancers and asthma, as diagnosed by a physician, Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer. Mass spectral data from each population is compared to determine proteins with expression intensities which are significantly differentially expressed between the normal, asthma, and lung cancer populations. Eleven proteins are found to have expression intensities which are significantly differentially expressed between the populations. Finally, the identity of the eleven proteins are obtained by comparing the mass spectral data with known databases having libraries of mass spectral data of known proteins.
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