-
1.发明公开FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 审中-公开KDNENSIERTE 1,4-DIHYDRODIOXIN-DERIVATE ALS INHIBITOREN DES HITZESCHOCK-TRANSKRIPTIONS FAKTORS 1
公开(公告)号：EP3052492A1
公开(公告)日：2016-08-10
申请号：EP14781644.1
申请日：2014-10-03
发明人： JONES, Keith , RYE, Carl , CHESSUM, Nicola , CHEESEMAN, Matthew , PASQUA, Adele Elisa , PIKE, Kurt Gordon , FAULDER, Paul Frank
IPC分类号： C07D405/14 , C07D319/08 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/056 , A61P35/00 , A61K31/357 , A61K31/404 , A61K31/428 , A61K31/436
CPC分类号： C07D405/12 , C07D319/18 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/056
摘要： The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及本文定义的式I化合物。 本发明的化合物是热休克因子1（HSF1）的抑制剂。 特别地，本发明涉及这些化合物作为治疗和/或预防增殖性疾病如癌症的治疗剂的用途。 本发明还涉及制备这些化合物的方法，以及包含它们的药物组合物。
-
公开(公告)号：EP3052492B1
公开(公告)日：2019-03-27
申请号：EP14781644.1
申请日：2014-10-03
发明人： JONES, Keith , RYE, Carl , CHESSUM, Nicola , CHEESEMAN, Matthew , PASQUA, Adele Elisa , PIKE, Kurt Gordon , FAULDER, Paul Frank
IPC分类号： C07D405/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/056 , A61P35/00 , A61K31/357 , A61K31/404 , A61K31/428 , A61K31/436 , C07D319/18
-
3.发明公开QUINOLINE DERIVATIVES AS INHIBITORS OF HEAT SHOCK FACTOR 1 PATHWAY ACTIVITY 审中-公开喹啉衍生物作为热休克因子1途径活性的抑制剂
公开(公告)号：EP3283484A1
公开(公告)日：2018-02-21
申请号：EP16715071.3
申请日：2016-04-01
发明人： JONES, Keith , CHEESEMAN, Matthew , CHESSUM, Nicola , PASQUA, Elisa , EVANS, Lindsay , TUCKER, Michael , WILDING, Birgit , MOK, Ngai, Yi
IPC分类号： C07D405/12 , A61K31/4709 , A61P35/00
CPC分类号： C07D215/48 , C07D405/12
摘要： wherein R, R4 and Q are each as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 pathway (HSF1 pathway). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
-
-
搜索结果
3 条记录 (耗时 0.019 秒)
