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1.发明公开2-[3H-THIAZOL-2-YLIDINEMETHYL]PYRIDINES AND RELATED COMPOUNDS AND THEIR USE 审中-公开2- [3H-噻唑-2- YLIDINMETHYL]吡啶和相关化合物及其用途
公开(公告)号：EP2029584A2
公开(公告)日：2009-03-04
申请号：EP07705241.3
申请日：2007-02-21
发明人： BROWN, Robert , PLUMB, Jane , AHERNE, Gladys, Wynne , MCDONALD, Edward , JONES, Keith , HILTON, Stephen
IPC分类号： C07D417/06 , C07D513/04 , A61K31/4439 , A61P35/00
CPC分类号： C07D513/04 , C07D417/06
摘要： The present invention pertains to certain 2-[3H-thiazol-2-ylidinemethyl]pyridine compounds and analogs thereof, which, inter alia, inhibit cell proliferation, treat cancer, etc., and more specifically to compounds of the following formula, wherein RA1, RA2, RA3, RA4, RB1, RB2, RNA, RNB, and X- are as defined herein. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative conditions such as cancer, etc.
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公开(公告)号：EP3052492B1
公开(公告)日：2019-03-27
申请号：EP14781644.1
申请日：2014-10-03
发明人： JONES, Keith , RYE, Carl , CHESSUM, Nicola , CHEESEMAN, Matthew , PASQUA, Adele Elisa , PIKE, Kurt Gordon , FAULDER, Paul Frank
IPC分类号： C07D405/14 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/056 , A61P35/00 , A61K31/357 , A61K31/404 , A61K31/428 , A61K31/436 , C07D319/18
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3.发明公开QUINOLINE DERIVATIVES AS INHIBITORS OF HEAT SHOCK FACTOR 1 PATHWAY ACTIVITY 审中-公开喹啉衍生物作为热休克因子1途径活性的抑制剂
公开(公告)号：EP3283484A1
公开(公告)日：2018-02-21
申请号：EP16715071.3
申请日：2016-04-01
发明人： JONES, Keith , CHEESEMAN, Matthew , CHESSUM, Nicola , PASQUA, Elisa , EVANS, Lindsay , TUCKER, Michael , WILDING, Birgit , MOK, Ngai, Yi
IPC分类号： C07D405/12 , A61K31/4709 , A61P35/00
CPC分类号： C07D215/48 , C07D405/12
摘要： wherein R, R4 and Q are each as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 pathway (HSF1 pathway). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
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公开(公告)号：EP3523295A1
公开(公告)日：2019-08-14
申请号：EP17783566.7
申请日：2017-10-06
IPC分类号： C07D405/12 , A61K31/4709 , A61P35/00
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5.发明公开FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1 审中-公开KDNENSIERTE 1,4-DIHYDRODIOXIN-DERIVATE ALS INHIBITOREN DES HITZESCHOCK-TRANSKRIPTIONS FAKTORS 1
公开(公告)号：EP3052492A1
公开(公告)日：2016-08-10
申请号：EP14781644.1
申请日：2014-10-03
发明人： JONES, Keith , RYE, Carl , CHESSUM, Nicola , CHEESEMAN, Matthew , PASQUA, Adele Elisa , PIKE, Kurt Gordon , FAULDER, Paul Frank
IPC分类号： C07D405/14 , C07D319/08 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/056 , A61P35/00 , A61K31/357 , A61K31/404 , A61K31/428 , A61K31/436
CPC分类号： C07D405/12 , C07D319/18 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/08 , C07D491/056
摘要： The present invention relates to compounds of formula I as defined herein. The compounds of the present invention are inhibitors of heat shock factor 1 (HSF1). In particular, the present invention relates to the use of these compounds as therapeutic agents for the treatment and/or prevention of proliferative diseases, such as cancer. The present invention also relates to processes for the preparation of these compounds, and to pharmaceutical compositions comprising them.
摘要翻译： 本发明涉及本文定义的式I化合物。 本发明的化合物是热休克因子1（HSF1）的抑制剂。 特别地，本发明涉及这些化合物作为治疗和/或预防增殖性疾病如癌症的治疗剂的用途。 本发明还涉及制备这些化合物的方法，以及包含它们的药物组合物。
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