公开(公告)号：EP4219720A2

公开(公告)日：2023-08-02

申请号：EP22208929.4

申请日：2019-06-12

申请人： Caribou Biosciences, Inc.

发明人： CAMERON, Peter, Sean ,  GRADIA, Scott, David ,  KLOMPE, Sanne, Eveline ,  STERNBERG, Samuel, Henry ,  THOMPSON, Matthew, Scott

IPC分类号： C12N15/62 ,  C12N9/16 ,  A61K48/00

摘要： The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.

公开(公告)号：EP4219720A3

公开(公告)日：2023-08-30

申请号：EP22208929.4

申请日：2019-06-12

申请人： Caribou Biosciences, Inc.

发明人： CAMERON, Peter, Sean ,  GRADIA, Scott, David ,  KLOMPE, Sanne, Eveline ,  STERNBERG, Samuel, Henry ,  THOMPSON, Matthew, Scott

IPC分类号： C12N15/62 ,  C12N9/16 ,  A61K48/00

摘要： The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides. Also, disclosed are methods for making and using the engineered Class 1 Type I CRISPR-Cas systems of the present invention.