公开(公告)号：EP2838533A1

公开(公告)日：2015-02-25

申请号：EP13779034.1

申请日：2013-04-16

申请人： Case Western Reserve University ,  Board of Regents of the University of Texas System ,  University of Kentucky

发明人： MARKOWITZ, Sanford ,  WILLSON, James, K.V. ,  POSNER, Bruce, A. ,  READY, Joseph ,  ZHANG, Yongyou ,  TAI, Hsin-Hsiung ,  MOSS, Melissa ,  ANTCZAK, Monika ,  GERSON, Stanton ,  DESAI, Amar ,  BAE, Kibeom ,  YANG, Sung Yeun

IPC分类号： A61K31/4365 ,  A61K31/4462 ,  C07D495/04 ,  A61P17/02 ,  A61P29/00

CPC分类号： C07D495/04 ,  A61K31/4365 ,  A61K31/519 ,  C07C311/21 ,  C07C2601/14 ,  C07D207/263 ,  C07D209/08 ,  C07D213/71 ,  C07D213/73 ,  C07D213/75 ,  C07D213/76 ,  C07D215/08 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D275/03 ,  C07D277/46 ,  C07D295/185 ,  C07D405/12

摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.

公开(公告)号：EP2838533B1

公开(公告)日：2017-10-04

申请号：EP13779034.1

申请日：2013-04-16

申请人： Case Western Reserve University ,  Board of Regents of the University of Texas System ,  University of Kentucky

发明人： MARKOWITZ, Sanford ,  WILLSON, James, K.V. ,  POSNER, Bruce, A. ,  READY, Joseph ,  ZHANG, Yongyou ,  TAI, Hsin-Hsiung ,  MOSS, Melissa ,  ANTCZAK, Monika ,  GERSON, Stanton ,  DESAI, Amar ,  BAE, Kibeom ,  YANG, Sung Yeun

IPC分类号： A61K31/4365 ,  A61K31/4462 ,  C07D495/04 ,  A61P17/02 ,  A61P29/00

CPC分类号： C07D495/04 ,  A61K31/4365 ,  A61K31/519 ,  C07C311/21 ,  C07C2601/14 ,  C07D207/263 ,  C07D209/08 ,  C07D213/71 ,  C07D213/73 ,  C07D213/75 ,  C07D213/76 ,  C07D215/08 ,  C07D237/20 ,  C07D239/42 ,  C07D241/20 ,  C07D261/14 ,  C07D275/03 ,  C07D277/46 ,  C07D295/185 ,  C07D405/12

摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.