公开(公告)号：EP3368661A1

公开(公告)日：2018-09-05

申请号：EP16795439.5

申请日：2016-10-26

申请人： Cell Cure Neurosciences Ltd. ,  Hadasit Medical Research Services and Development Ltd.

发明人： REUBINOFF, Benjamin Eithan ,  SINGER, Orna ,  BOHANA-KASHTAN, Osnat ,  WISER, Ofer

IPC分类号： C12N5/079

CPC分类号： C12N5/0621 ,  C12N5/0018 ,  C12N5/0606 ,  C12N2501/15 ,  C12N2501/16 ,  C12N2501/999 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2509/00 ,  C12N2533/52 ,  C12N2533/54 ,  G01N33/53

摘要： A method of generating retinal pigment epithelium cells is disclosed. Cell populations comprising same and uses thereof are also disclosed.

公开(公告)号：EP3328995A1

公开(公告)日：2018-06-06

申请号：EP16750270.7

申请日：2016-07-28

申请人： Hadasit Medical Research Services and Development Ltd.

发明人： REUBINOFF, Benjamin Eithan ,  SINGER, Orna

IPC分类号： C12N5/079

CPC分类号： C12N5/0621 ,  A61K9/0051 ,  A61K35/30 ,  A61P27/02 ,  C12N2500/38 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2502/13 ,  C12N2506/02 ,  C12N2533/52 ,  C12N2533/54

摘要： A method of generating retinal pigment epithelial (RPE) cells is disclosed. The method comprises: (a) culturing human pluripotent stem cells in a human feeder cell-conditioned medium to obtain a cultured population of human pluripotent stem cells; (b) culturing said cultured population of human pluripotent stem cells in a medium comprising a differentiating agent to obtain differentiating cells; and (c) culturing said differentiating cells in a medium comprising one or more members of the TGFβ superfamily.