公开(公告)号：EP2002263A2

公开(公告)日：2008-12-17

申请号：EP07754126.6

申请日：2007-03-29

申请人： Cell Genesys Inc. ,  The Regents of the University of California

发明人： SIMMONS, Andrew ,  JOOSS, Karin ,  ALLISON, James

IPC分类号： G01N33/574

CPC分类号： A61K39/0011 ,  A61K39/0008 ,  A61K39/39 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5152 ,  A61K2039/55516 ,  A61K2039/55522 ,  C07K16/2818

摘要： Cellular compositions and methods for inducing an immune response to tumor cells are described. The cellular compositions include a tumor antigen and cells that have been modified to express a cytokine and one or more of a tumor antigen, an anti-CTLA4 antibody and an additional cytokine. The cellular compositions find utility in methods for treating cancer.

公开(公告)号：EP2002263B1

公开(公告)日：2014-06-04

申请号：EP07754126.6

申请日：2007-03-29

申请人： Aduro GVAX Inc. ,  The Regents of the University of California

发明人： SIMMONS, Andrew ,  JOOSS, Karin ,  ALLISON, James

IPC分类号： A61K39/00 ,  C07K16/28 ,  A61K38/00

CPC分类号： A61K39/0011 ,  A61K39/0008 ,  A61K39/39 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5152 ,  A61K2039/55516 ,  A61K2039/55522 ,  C07K16/2818

公开(公告)号：EP1636360A1

公开(公告)日：2006-03-22

申请号：EP04801855.0

申请日：2004-04-26

申请人： CELL GENESYS, INC.

发明人： FANG, Jianmin ,  JOOSS, Karin ,  SIMMONS, Andrew ,  QIAN, Jing-Jing

IPC分类号： C12N15/00 ,  C12N15/64 ,  C12N15/63 ,  C12N15/86 ,  C12P21/06 ,  C07H21/04 ,  C07K1/00

CPC分类号： C12N15/86 ,  C07K16/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/30 ,  C07K2319/50 ,  C12N15/8273 ,  C12N2750/14143 ,  C12N2800/60 ,  C12N2830/00 ,  C12N2830/15 ,  C12N2830/42 ,  C12N2830/48 ,  C12N2830/85 ,  C12N2830/90 ,  C12N2840/203

摘要： Vector constructs for expression of two or more functional proteins or polypeptides under operative control of a single promoter and methods of making and using the same are described. The vectors comprise a self-processing cleavage site between each respective protein or polypeptide coding sequence. The vector constructs include the coding sequence for a self-processing cleavage site and may further include an additional proteolytic cleavage sequence which provides a means to remove the self processing peptide sequence from expressed protein(s) or polypeptide(s). The vector constructs find utility in methods for enhanced production of biologically active proteins and polypeptides in vitro and in vivo.