公开(公告)号：EP1146885A1

公开(公告)日：2001-10-24

申请号：EP00900465.6

申请日：2000-01-11

申请人： Centre De Recherche Du Centre Hospitalier De L'Universite De Montreal ,  Vasogen Ireland Limited

发明人： HAMET, Pavel,c/o Chum, Pavilion Hotel-Dieu ,  TREMBLAY, Johanne,c/o Chum, Pavilion Hotel-Dieu ,  DESROSIER, Christine ,  CHENG, Huifang

IPC分类号： A61K35/14

CPC分类号： A61K35/14 ,  A61K41/0019 ,  A61M1/0281 ,  A61M1/3681 ,  A61M1/3683 ,  A61M1/3687 ,  A61M1/369 ,  A61M2202/0216 ,  A61M2205/053

摘要： Apoptosis and/or necrosis related disorders in the mammalian body, namely radiation exposure disorders, chemical exposure and ingestion disorders, neurological disorders and physical trauma disorders, are treated, and their onset is counteracted by pre-conditioning, by extracting from the mammalian body an aliquot of blood, subjecting the extracted aliquot, ex vivo, to an oxidative stressor such as exposure to ozone gas, a temperature stressor, i.e. temperatures above or below body temperatures, and ultraviolet light, and re-injecting the treated blood aliquot into the mammalian body. The treatment has the effect of decreasing apoptosis/necrosis in the body, and of pre-conditioning the body better to withstand subsequently encountered apoptosis-inducing events.

摘要翻译： 治疗哺乳动物身体中的细​​胞凋亡和/或坏死相关疾病，即放射线暴露障碍，化学暴露和摄入障碍，神经障碍和身体创伤障碍，并通过预处理来抵消它们的发作，通过从哺乳动物体内提取 将血液等分试样，离体将经过提取的等分试样经受氧化应激源，例如暴露于臭氧气体，温度胁迫器，即高于或低于体温的温度和紫外线，并将经处理的血液等分试样重新注入哺乳动物 身体。 该治疗具有减少身体凋亡/坏死的作用，并且更好地预处理身体以抵抗随后遇到的凋亡诱导事件。