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1.发明授权A NOVEL BIOLOGICAL CANCER MARKER AND METHODS FOR DETERMINING THE CANCEROUS OR NON-CANCEROUS PHENOTYPE OF CELLS 有权一种新的肿瘤标志物和方法用于癌症等的检测OR NOT LIKE癌细胞表型
公开(公告)号：EP1502113B1
公开(公告)日：2009-08-12
申请号：EP03749868.0
申请日：2003-05-06
发明人： ROUX, Pierre , GADEA, Gilles
IPC分类号： G01N33/574
CPC分类号： G01N33/57492
摘要： The present invention relates to the use of the frequency value of filopodia generation in a sample cell population as a biological marker for determining the cancerous, metastatic cancerous or normal phenotype of said cell population. It also relates to a method for determining in vitro the cancerous, metastatic cancerous or normal phenotype of cells contained in a sample, wherein said method comprises a step of in vitro measuring the frequency of filopodia generation in the cells contained in the sample. The present invention further concerns methods for the screening of the carcinogenic properties of a compound or of the metastatic properties of a compound which make use of the general method described above.
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公开(公告)号：EP3250683B1
公开(公告)日：2020-10-07
申请号：EP16703464.4
申请日：2016-02-01
发明人： ROUX, Pierre , ARSIC, Nikola , GADEA, Gilles , FORT, Philippe , THOMAS, Fanny , GIRE, Véronique
IPC分类号： G01N33/574 , C12N5/095 , A61K31/704 , A61K31/7048
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公开(公告)号：EP3250679B1
公开(公告)日：2020-08-19
申请号：EP16702146.8
申请日：2016-02-01
发明人： ROUX, Pierre , ARSIC, Nikola , GADEA, Gilles , FORT, Philippe , RAYNAUD, Peggy
IPC分类号： C12N5/074
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公开(公告)号：EP3474891A1
公开(公告)日：2019-05-01
申请号：EP17733424.0
申请日：2017-06-22
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de la Réunion Saint Denis , Institut de Recherche pour le Développement (IRD) , Centre National de la Recherche Scientifique (CNRS)
IPC分类号： A61K39/12
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公开(公告)号：EP3838290A1
公开(公告)日：2021-06-23
申请号：EP20212555.5
申请日：2017-06-22
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de la Réunion Saint Denis , Institut De Recherche Pour Le Développement (IRD) , Centre National de la Recherche Scientifique (CNRS)
IPC分类号： A61K39/12
摘要： The present invention relates to vaccine compositions comprising an attenuated mutant Zika virus. The inventors have introduced mutations at very specific positions that abrogate the N-glycosylation site on the E protein of the epidemic strain which will prevent the generation of auto-antibodies responsible for Guillain-Barre syndrome. The inventors have also produced additional mutations of the virus that result to a dramatic reduction of the cytopathic effects without affecting the capacity to produce high titers of virus. In particular, the present invention relates to an attenuated mutant Zika virus comprising a protein E of the epidemic strain wherein at least one amino acid residue at position 152, 156 or 158 is mutated.
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公开(公告)号：EP3481848A1
公开(公告)日：2019-05-15
申请号：EP17739939.1
申请日：2017-07-07
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université de la Réunion Saint Denis , Institut de Recherche pour le Développement (IRD) , Centre National de la Recherche Scientifique (CNRS)
IPC分类号： C07K14/005 , C12N7/04 , C12N15/113
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7.发明授权METHOD FOR TESTING A SUBJECT THOUGHT TO BE PREDISPOSED TO HAVING METASTATIC CANCER USING DELTA133P53 ISOFORMS 有权METHOD FOR测试人用怀疑甲PRÄDSPOSITION学报转移性癌症USING DELTA133P53异构体的表达
公开(公告)号：EP2449133B1
公开(公告)日：2016-08-03
申请号：EP10731498.1
申请日：2010-06-30
申请人： Centre National de la Recherche Scientifique (CNRS) , University Of Dundee , Université Montpellier 2 Sciences et Techniques
发明人： ROUX, Pierre , GADEA, Gilles , VINOT, Stéphanie , ANGUILLE, Christelle , BOURDON, Jean-Christophe , FERNANDES, Kenneth
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N2333/4748 , G01N2500/10 , G01N2800/52 , G01N2800/56
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8.发明公开METHOD FOR TESTING A SUBJECT THOUGHT TO BE PREDISPOSED TO HAVING METASTATIC CANCER USING DELTA133P53BETA 有权METHOD FOR测试人用怀疑甲PRÄDSPOSITION学报转移性癌症USING DELTA133P53异构体的表达
公开(公告)号：EP2449133A1
公开(公告)日：2012-05-09
申请号：EP10731498.1
申请日：2010-06-30
发明人： ROUX, Pierre , GADEA, Gilles , VINOT, Stéphanie , ANGUILLE, Christelle , BOURDON, Jean-Christophe , FERNANDES, Kenneth
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N2333/4748 , G01N2500/10 , G01N2800/52 , G01N2800/56
摘要： The present invention concerns a method of testing a subject thought to be predisposed to having a metastatic cancer which comprises the step of i) analyzing a biological sample from said subject for detecting the presence of a p53 isoform selected in the group consisting in Δ133p53, Δ133p53γ and Δ133p53β, the presence of said p53 isoform being indicative of a metastatic cancer.
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9.发明公开A NOVEL BIOLOGICAL CANCER MARKER AND METHODS FOR DETERMINING THE CANCEROUS OR NON-CANCEROUS PHENOTYPE OF CELLS 有权一种新的肿瘤标志物和方法用于癌症等的检测OR NOT LIKE癌细胞表型
公开(公告)号：EP1502113A1
公开(公告)日：2005-02-02
申请号：EP03749868.0
申请日：2003-05-06
发明人： ROUX, Pierre , GADEA, Gilles
IPC分类号： G01N33/574
CPC分类号： G01N33/57492
摘要： The present invention relates to the use of the frequency value of filopodia generation in a sample cell population as a biological marker for determining the cancerous, metastatic cancerous or normal phenotype of said cell population. It also relates to a method for determining in vitro the cancerous, metastatic cancerous or normal phenotype of cells contained in a sample, wherein said method comprises a step of in vitro measuring the frequency of filopodia generation in the cells contained in the sample. The present invention further concerns methods for the screening of the carcinogenic properties of a compound or of the metastatic properties of a compound which make use of the general method described above.
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