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1.发明授权METHOD FOR TESTING A SUBJECT THOUGHT TO BE PREDISPOSED TO HAVING METASTATIC CANCER USING DELTA133P53 ISOFORMS 有权METHOD FOR测试人用怀疑甲PRÄDSPOSITION学报转移性癌症USING DELTA133P53异构体的表达
公开(公告)号：EP2449133B1
公开(公告)日：2016-08-03
申请号：EP10731498.1
申请日：2010-06-30
申请人： Centre National de la Recherche Scientifique (CNRS) , University Of Dundee , Université Montpellier 2 Sciences et Techniques
发明人： ROUX, Pierre , GADEA, Gilles , VINOT, Stéphanie , ANGUILLE, Christelle , BOURDON, Jean-Christophe , FERNANDES, Kenneth
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N2333/4748 , G01N2500/10 , G01N2800/52 , G01N2800/56
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2.发明公开SIGNATURE FOR THE DIAGNOSIS OF BREAST CANCER AGGRESSIVENESS AND GENETIC INSTABILITY 有权签名乳腺癌侵袭性和遗传不稳定性的诊断
公开(公告)号：EP2499258A1
公开(公告)日：2012-09-19
申请号：EP10776712.1
申请日：2010-11-12
申请人： Centre National de la Recherche Scientifique CNRS , Universite Paul Sabatier Toulouse III , Institut Claudius Regaud
发明人： CAZAUX, Christophe , HOFFMANN, Jean-Sébastien , BOURDON, Jean-Christophe , MACHADO DA SILVA, Alice , ROCHE, Henri
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a breast cancer in a patient from a breast cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient breast cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient breast cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing breast cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
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3.发明公开METHOD FOR TESTING A SUBJECT THOUGHT TO BE PREDISPOSED TO HAVING METASTATIC CANCER USING DELTA133P53BETA 有权METHOD FOR测试人用怀疑甲PRÄDSPOSITION学报转移性癌症USING DELTA133P53异构体的表达
公开(公告)号：EP2449133A1
公开(公告)日：2012-05-09
申请号：EP10731498.1
申请日：2010-06-30
发明人： ROUX, Pierre , GADEA, Gilles , VINOT, Stéphanie , ANGUILLE, Christelle , BOURDON, Jean-Christophe , FERNANDES, Kenneth
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N2333/4748 , G01N2500/10 , G01N2800/52 , G01N2800/56
摘要： The present invention concerns a method of testing a subject thought to be predisposed to having a metastatic cancer which comprises the step of i) analyzing a biological sample from said subject for detecting the presence of a p53 isoform selected in the group consisting in Δ133p53, Δ133p53γ and Δ133p53β, the presence of said p53 isoform being indicative of a metastatic cancer.
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4.发明授权SIGNATURE FOR THE DIAGNOSIS OF BREAST CANCER AGGRESSIVENESS AND GENETIC INSTABILITY 有权签名乳腺癌侵袭性和遗传不稳定性的诊断
公开(公告)号：EP2499258B1
公开(公告)日：2014-08-06
申请号：EP10776712.1
申请日：2010-11-12
申请人： Centre National de la Recherche Scientifique (CNRS) , Université Paul Sabatier Toulouse III , Institut Claudius Regaud
发明人： CAZAUX, Christophe , HOFFMANN, Jean-Sébastien , BOURDON, Jean-Christophe , MACHADO DA SILVA, Alice , ROCHE, Henri
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
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5.发明授权PROCEDE POUR AMELIORER LA PRODUCTION DE VIRUS ET SEMENCES VACCINALES INFLUENZA 有权PROCEDE POUR AMELIORER LA生产DE病毒胚胎疫苗流感病毒
公开(公告)号：EP2635302B1
公开(公告)日：2017-05-24
申请号：EP11802469.4
申请日：2011-11-04
申请人： University of Dundee , Centre National de la Recherche Scientifique , Université Claude Bernard Lyon I , Hospices Civils de Lyon
IPC分类号： A61K39/145 , C12N7/02
CPC分类号： A61K39/145 , A61K39/12 , C12N7/00 , C12N2760/16051 , C12N2760/16151
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6.发明公开PROCEDE POUR AMELIORER LA PRODUCTION DE VIRUS ET SEMENCES VACCINALES INFLUENZA 有权VERFAHREN ZUR VERBESSERUNG DER HERSTELLUNG VON INFLUENZAVIREN UND IMPFKRISTALLEN
公开(公告)号：EP2635302A1
公开(公告)日：2013-09-11
申请号：EP11802469.4
申请日：2011-11-04
申请人： University of Dundee , Centre National de la Recherche Scientifique , Université Claude Bernard Lyon I , Les Hospices Civils de Lyon
IPC分类号： A61K39/145 , C12N7/02
CPC分类号： A61K39/145 , A61K39/12 , C12N7/00 , C12N2760/16051 , C12N2760/16151
摘要： The present invention relates to a method for improving the production of an influenza virus, and in particular influenza vaccine seeds, or a vaccine directed against an influenza virus, characterized in that the production is carried out in the presence of an inhibitor of the interaction between the Mdm2 protein and the p53 protein.
摘要翻译： 本发明涉及一种用于改善流感病毒，特别是流感疫苗种子或针对流感病毒的疫苗的生产方法，其特征在于，所述生产是在存在下的相互作用的抑制剂的情况下进行的 Mdm2蛋白和p53蛋白。
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