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    METHODS FOR PREDICTING RESPONSE TO DNA REPAIR PATHWAY INHIBITORS IN DIFFUSE LARGE B-CELL LYMPHOMA
    5.
    发明公开
    METHODS FOR PREDICTING RESPONSE TO DNA REPAIR PATHWAY INHIBITORS IN DIFFUSE LARGE B-CELL LYMPHOMA 有权
    预测弥散性大B细胞淋巴瘤DNA修复通路抑制剂反应的方法

    公开(公告)号：EP3172338A1

    公开(公告)日：2017-05-31

    申请号：EP15741568.8

    申请日：2015-07-27

    申请人： INSERM - Institut National de la Santé et de la Recherche Médicale ,  Université de Montpellier ,  Centre Hospitalier Universitaire de Montpellier ,  Centre National de la Recherche Scientifique (C.N.R.S.)

    发明人： MOREAUX, Jérôme ,  CARTRON, Guillaume ,  BRET, Caroline ,  CONSTANTINOU, Angelos ,  PASERO, Philippe

    IPC分类号： C12Q1/68 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G06F19/00 ,  G06F19/18 ,  G06F19/20 ,  G06F19/24 ,  G16H50/30

    摘要： The present invention relates to a method of testing whether a patient suffering from arge B-cell lymphoma will respond or not to a DNA repair pathway inhibitor comprising: i) determining the expression level (ELi) of several genes Gi-Gn selected from table A in a biological sample obtained from said patient comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii) calculating the DNA repair score trough the following formula (I), wherein βi represent the regression β coefficient reference value for the gene Gi and Ci = 1 if the expression of the gene Gi (ELi) is higher than the predetermined reference level (ELRi) or Ci = -1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) iv) comparing the score DNARS determined at step iii) with a predetermined reference value DNARSR v) and concluding that the patient will respond to the treatment when the DNARS score is higher than the predetermined reference value DNARSR or concluding that the patient will not respond to the treatment when the DNARS score is lower than the predetermined reference value DNARSR.

    摘要翻译： 本发明涉及测试罹患大B细胞淋巴瘤的患者是否将响应DNA修复途径抑制剂的方法，包括：i）测定​​选自表A的几种基因Gi-Gn的表达水平（ELi） 在从所述患者获得的生物样品中比较在步骤i）确定的表达水平（ELi）与预定参考水平（ELRi）iii）通过下式（I）计算DNA修复分数，其中βi表示回归β系数 如果基因Gi（ELi）的表达高于预定参考水平（ELRi），或者如果基因（ELi）的表达低于或等于Ci = -1，则基因Gi和Ci = 1的参考值 所述预定参考水平（ELRi）iv）将步骤iii）中确定的评分DNARS与预定参考值DNARSR v）进行比较，并且推断当DNARS评分高于所述预定参数时所述患者将对所述治疗作出响应 挖掘参考值DNARSR或得出结论：当DNARS评分低于预定参考值DNARSR时，患者不会对治疗做出反应。