公开(公告)号：EP2499258B1

公开(公告)日：2014-08-06

申请号：EP10776712.1

申请日：2010-11-12

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Université Paul Sabatier Toulouse III ,  Institut Claudius Regaud

发明人： CAZAUX, Christophe ,  HOFFMANN, Jean-Sébastien ,  BOURDON, Jean-Christophe ,  MACHADO DA SILVA, Alice ,  ROCHE, Henri

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

公开(公告)号：EP2499258A1

公开(公告)日：2012-09-19

申请号：EP10776712.1

申请日：2010-11-12

申请人： Centre National de la Recherche Scientifique CNRS ,  Universite Paul Sabatier Toulouse III ,  Institut Claudius Regaud

发明人： CAZAUX, Christophe ,  HOFFMANN, Jean-Sébastien ,  BOURDON, Jean-Christophe ,  MACHADO DA SILVA, Alice ,  ROCHE, Henri

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a breast cancer in a patient from a breast cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient breast cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient breast cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing breast cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.