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1.发明授权SIGNATURE FOR THE DIAGNOSIS OF BREAST CANCER AGGRESSIVENESS AND GENETIC INSTABILITY 有权签名乳腺癌侵袭性和遗传不稳定性的诊断
公开(公告)号：EP2499258B1
公开(公告)日：2014-08-06
申请号：EP10776712.1
申请日：2010-11-12
申请人： Centre National de la Recherche Scientifique (CNRS) , Université Paul Sabatier Toulouse III , Institut Claudius Regaud
发明人： CAZAUX, Christophe , HOFFMANN, Jean-Sébastien , BOURDON, Jean-Christophe , MACHADO DA SILVA, Alice , ROCHE, Henri
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
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2.发明公开SIGNATURE FOR THE DIAGNOSIS OF BREAST CANCER AGGRESSIVENESS AND GENETIC INSTABILITY 有权签名乳腺癌侵袭性和遗传不稳定性的诊断
公开(公告)号：EP2499258A1
公开(公告)日：2012-09-19
申请号：EP10776712.1
申请日：2010-11-12
申请人： Centre National de la Recherche Scientifique CNRS , Universite Paul Sabatier Toulouse III , Institut Claudius Regaud
发明人： CAZAUX, Christophe , HOFFMANN, Jean-Sébastien , BOURDON, Jean-Christophe , MACHADO DA SILVA, Alice , ROCHE, Henri
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a breast cancer in a patient from a breast cancer sample of said patient, comprising: a) measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in said patient breast cancer sample; b) calculating for said POLQ gene an expression level ratio of the expression level of POLQ to the expression of the said control gene in said patient breast cancer sample; c) comparing the said POLQ expression level ratio to a corresponding threshold value, and d) diagnosing breast cancer aggressiveness and genetic instability if the said POLQ expression level ratio is superior to a corresponding threshold values. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
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公开(公告)号：EP3131930B1
公开(公告)日：2019-02-06
申请号：EP15715289.3
申请日：2015-04-14
申请人： Centre National de la Recherche Scientifique (C.N.R.S.) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paul Sabatier Toulouse III
IPC分类号： C07K16/40
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4.发明公开ANTICORPS RECONNAISSANT LE DOMAINE CENTRAL DE L'ADN POLYMERASE POL THETA ET LEURS UTILISATIONS POUR LE DIAGNOSTIC DU CANCER 审中-公开抗体DNA聚合酶POL-THETA和使用中央结构域用于癌症的诊断
公开(公告)号：EP3131930A1
公开(公告)日：2017-02-22
申请号：EP15715289.3
申请日：2015-04-14
申请人： Centre National de la Recherche Scientifique (C.N.R.S.) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université Paul Sabatier Toulouse III
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , C07K2317/34 , C07K2317/56 , C07K2317/565
摘要： The invention relates to a monoclonal antibody that is capable of attaching to the central domain of DNA polymerase Pol Theta.
摘要翻译： 本发明涉及一种单克隆抗体确实能够附着到DNA聚合酶聚合酶theta的中央结构域组成。
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5.发明公开
公开(公告)号：EP2800821A1
公开(公告)日：2014-11-12
申请号：EP13700490.9
申请日：2013-01-07
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to a method for diagnosing aggressiveness of a lung cancer in a patient from a lung cancer sample of the patient, comprising: a) detecting in vitro an expression profile of the DNA replication stress signature, the signature comprising the CDC6, CLASPIN, PLK1, and POLQ genes, as well as, optionally, RAD51; b) comparing the the expression profile to a reference expression profile, and d) diagnosing cancer aggressiveness from the comparison. Dedicated microarrays and kits are also described, as well as a method of selecting or adapting a suitable treatment.
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