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1.发明公开DERIVE DE RESVERATROL A LONGUE CHAINE HYDROXYLEE UTILES COMME NEUROTROPHIQUES 审中-公开羟基化，长链RESVERATROLDERIVATE引致的，一个是指适合嗜神经
公开(公告)号：EP1991516A2
公开(公告)日：2008-11-19
申请号：EP07712425.3
申请日：2007-03-02
发明人： LUU, Bang , HAUSS, Frédérique , COOWAR, Djalil , LIU, Jiawei , HEUSCHLING, Paul , MORGA, Eleonora , GRANDBARBE, Luc , MICHELUCCI, Alessandro
摘要： The present invention relates to a compound of general formula (I) below in which R1, R2 and R3 represent, independently of one another, a hydrogen atom or a C1-C6 alkyl group or a (C1-C6 alkyl)carbonyl group, R4, R5, R6 and R7 represent a hydrogen or a C1-C6 alkyl group, a C1-C6 alkoxy group or a (C1-C6 alkyl)carbonyloxy group, and n is an integer between 8 and 20, or its pharmaceutically acceptable addition salts, isomers, enantiomers and diastereoisomers, and also mixtures thereof. The invention also relates to a pharmaceutical composition comprising the compound and to the use thereof as a neurotrophic agent.
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2.发明公开DERIVES DE TOCOPHEROL A LONGUE CHAINE HYDROXYLEE UTILES COMME NEUROTROPHIQUES 有权用长链生育酚羟基化所产生的一种手段安装神经营养LEAVE
公开(公告)号：EP1664012A1
公开(公告)日：2006-06-07
申请号：EP04787448.2
申请日：2004-09-24
申请人： UNIVERSITE LOUIS PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Universite du Luxembourg
发明人： LUU, Bang , HEUSCHLING, Paul , MULLER, Thierry , MORGA, Eleonora
IPC分类号： C07D311/72 , C07D313/08 , A61K31/335 , A61K31/355 , A61P25/28
CPC分类号： C07D311/72 , C07D307/80
摘要： The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula (I), which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia and/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula (I).
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3.发明授权DERIVES DE TOCOPHEROL A LONGUE CHAINE HYDROXYLEE UTILES COMME NEUROTROPHIQUES 有权用长链生育酚羟基化所产生的一种手段安装神经营养LEAVE
公开(公告)号：EP1664012B1
公开(公告)日：2009-04-01
申请号：EP04787448.2
申请日：2004-09-24
申请人： UNIVERSITE LOUIS PASTEUR , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Université du Luxembourg
发明人： LUU, Bang , HEUSCHLING, Paul , MULLER, Thierry , MORGA, Eleonora
IPC分类号： C07D311/72 , C07D313/08 , A61K31/335 , A61K31/355 , A61P25/28
CPC分类号： C07D311/72 , C07D307/80
摘要： The invention relates to any isolated or synthetic compound and, in particular, to compounds having formula (I), which can: modulate the cell specification of neural stem cells, promote the differentiation and subsequent survival of differentiating glial cells and neurones, and promote the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes. In addition, the inventive compounds can reduce the inflammatory component of diseases that affect the nervous system, for example, by reducing activation of the microglia and/or astrocytes and/or by reducing reactive gliosis. The invention also relates to the methods of preparing such compounds and to the use of same in the preparation of a pharmaceutical composition that is intended for the prevention or treatment of diseases that affect the nervous system. More specifically, the inventive compounds have general formula (I).
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