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1.发明公开COMPOSITIONS COMPRISING MULTIVALENT SYNTHETIC LIGANDS OF SURFACE NUCLEOLIN AND GLYCOSAMINOGLYCANS 审中-公开成分多含VALENTE面及核仁粘多糖合成配体
公开(公告)号：EP2624848A2
公开(公告)日：2013-08-14
申请号：EP11764210.8
申请日：2011-10-04
申请人： Centre National de la Recherche Scientifique CNRS , Elro Pharma , Universite Paris 12 - Val De Marne
发明人： ZIMMER, Robert , COURTY, José
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K31/7068 , A61K31/726 , A61K31/727 , A61K36/00 , A61K36/02 , A61K36/10 , A61K38/06 , A61K38/16 , Y02A50/478 , Y02A50/481 , A61K2300/00
摘要： The present invention relates to a composition comprising a Nucant multivalent synthetic compound and a glycosaminoglycan, the admixture of both compounds forming microspheres comprising both compounds, as well as their use for the treatment or prevention of diseases associated with deregulation of proliferation and/or angiogenesis, such as cancer, inflammatory disease, or for promoting wound healing.
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公开(公告)号：EP2624849A2
公开(公告)日：2013-08-14
申请号：EP11764211.6
申请日：2011-10-04
申请人： Centre National de la Recherche Scientifique (C.N.R.S.) , Universite Paris 12 - Val De Marne , Elro Pharma
发明人： ZIMMER, Robert , COURTY, José
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K31/7068 , A61K31/726 , A61K31/727 , A61K36/00 , A61K36/02 , A61K36/10 , A61K38/06 , A61K38/16 , Y02A50/478 , Y02A50/481 , A61K2300/00
摘要： The present invention relates to a composition comprising a Nucant multivalent synthetic compound and a glycosaminoglycan, the admixture of both compounds forming microspheres comprising both compounds, as well as their use for the treatment or prevention of diseases associated with deregulation of proliferation and/or angiogenesis, such as cancer, inflammatory disease, or for promoting wound healing.
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公开(公告)号：EP2291390B1
公开(公告)日：2014-11-05
申请号：EP08807467.9
申请日：2008-05-22
发明人： BRIAND, Jean Paul , GUICHARD, Gilles , COURTY, José , ZIMMER, Robert , DEVIN, Chantal , LANG, Annie , ZHANG, Haixing , HOVANESSIAN, Ara
CPC分类号： C07K5/06086 , A61K38/00 , C07K7/06
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4.发明授权UTILISATION DE LIGANDS SYNTHETIQUES MULTIVALENTS DE LA NUCLEOLINE DE SURFACE POUR LE TRAITEMENT DU CANCER OU DE L'INFLAMMATION 有权USEOBERFLÄCHENNUKLEOLIN多价合成配体用于治疗癌症或炎症
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公开(公告)号：EP2448594A1
公开(公告)日：2012-05-09
申请号：EP10745672.5
申请日：2010-06-29
申请人： Centre National de la Recherche Scientifique CNRS , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , Université Paris Est Créteil Val De Marne
发明人： DELBE, Jean , AMICHE, Mohamed , LADRAM, Ali , GALANTH, Cécile , NICOLAS, Pierre , HAMMA, Yamina , VAN ZOGGEL, Johanna Allegonda Anna , COURTY, José
CPC分类号： C07K14/463 , A61K38/1703 , A61K38/4886 , A61K45/06 , C07K2319/00
摘要： The invention relates to the use of peptides corresponding to dermaseptin B2 or fragments thereof for treating proliferative diseases such as cancer or ocular lesions, and to pharmaceutical compositions containing such peptides.
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公开(公告)号：EP1556410B1
公开(公告)日：2012-07-04
申请号：EP03767862.0
申请日：2003-10-29
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A61K38/00
摘要： The invention concerns peptide fragments 13-39 and 65-97 of the HARP factor, which inhibit angiogenesis. Advantageously, said peptides can be associated with the peptide 111-136 of HARP. The invention also concerns pharmaceutical compositions comprising said peptides or nucleic acids encoding said peptides, and their use for treating pathologies associated with an angiogenesis, in particular proliferative disorders such as cancer.
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7.发明公开UTILISATION DE LIGANDS SYNTHETIQUES MULTIVALENTS DE LA NUCLEOLINE DE SURFACE POUR LE TRAITEMENT DU CANCER OU DE L'INFLAMMATION 有权USEOBERFLÄCHENNUKLEOLIN多价合成配体用于治疗癌症或炎症
公开(公告)号：EP2013232A2
公开(公告)日：2009-01-14
申请号：EP07731382.3
申请日：2007-04-22
IPC分类号： C07K14/16
CPC分类号： C07K14/4705 , A61K38/00 , A61K38/02 , A61K38/16 , C07K14/47
摘要： The present invention relates to the use of a polyvalent synthetic compound comprising a support on which at least 3 pseudopeptide units are grafted, said compound being of formula (I), in which each X independently represents any amino acid; Y
1 and Y
2 are selected independently from amino acids having a basic side chain; Z is selected from a proline, optionally substituted at ≠, - or..; a natural or non-natural N-alkylamino acid; a dialkylamino acid; a cyclic dialkylamino acid; pipecolic acid or a derivative thereof; n and i independently are 0 or 1; m is an integer between 0 and 3; k is an integer greater than or equal to 3; and Ψ represents a modified peptide bond which is significantly more resistant to at least one protease than a standard peptide bond, for preparing a medicament intended for treating a disease involving deregulation of cell proliferation and/or of angiogenesis, and preferably acting as a surface nucleolin ligand, or for treating inflammatory diseases.
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