公开(公告)号：EP4405380A2

公开(公告)日：2024-07-31

申请号：EP22786075.6

申请日：2022-09-23

申请人： Bastion Therapeutics Limited

发明人： NEWTON, Timothy ,  WLODEK, Aleksandra

IPC分类号： C07K14/47 ,  C07K14/705 ,  C07K14/725 ,  A61K35/17 ,  C07K16/18 ,  G01N33/00

CPC分类号： C07K14/4705 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70571 ,  C07K2319/0320130101 ,  C07K2319/7120130101 ,  A61P29/00 ,  C07K16/18 ,  C07K2317/62220130101 ,  A61K39/4611 ,  A61K2039/5556620130101 ,  A61K2039/5554420130101 ,  A61K39/4631 ,  A61K39/4643 ,  A61K39/46433 ,  A61K2239/3820230501 ,  A61K39/4621 ,  A61K2239/3120230501

公开(公告)号：EP4402265A1

公开(公告)日：2024-07-24

申请号：EP22801531.9

申请日：2022-09-15

申请人： Novartis AG

发明人： FERGUSON, Keith Everett ,  HROMADKA, Stephanie Viani ,  TAO, Xu E.

IPC分类号： C12N15/62 ,  C12N15/86 ,  A61P25/00

CPC分类号： C12N15/62 ,  A61P25/00 ,  C12N9/22 ,  C12N2740/1604320130101 ,  C12N2750/1414320130101 ,  C07K14/4705 ,  C07K2319/0920130101 ,  C07K2319/8020130101 ,  C07K2319/7120130101 ,  C07K2319/8120130101

公开(公告)号：EP4381047A1

公开(公告)日：2024-06-12

申请号：EP22757327.6

申请日：2022-08-03

申请人： Adaptimmune Limited

发明人： HAMILTON, Garth

IPC分类号： C12N5/0783 ,  A61P35/00

CPC分类号： A61P35/00 ,  C12N5/0636 ,  C12N2510/0020130101 ,  C12N2506/4520130101 ,  C12N2501/1620130101 ,  C12N2501/11520130101 ,  C12N2501/15520130101 ,  C12N2501/16520130101 ,  C12N2501/12520130101 ,  C12N2501/72720130101 ,  C07K14/7051 ,  C12N2750/1414120130101 ,  C07K2319/0320130101 ,  C07K14/4705 ,  A61K39/464486 ,  A61K39/4611 ,  A61K39/4632

公开(公告)号：EP4352085A1

公开(公告)日：2024-04-17

申请号：EP22819038.5

申请日：2022-06-09

申请人： Sunnybrook Research Institute ,  The Governing Council of The University of Toronto

发明人： SCHUURMANS, Carol ,  MCLAURIN, Joanne ,  MORSHEAD, Cindy ,  PARK, Eunjee ,  KEHTARI, Tarlan ,  VASAN, Lakshmy ,  FAIZ, Maryam ,  ENBAR, Tom

IPC分类号： C07K14/47 ,  A61K38/17 ,  A61P25/00 ,  A61P25/28 ,  C12N15/12 ,  C12N15/85 ,  C12N15/864

CPC分类号： A61P25/28 ,  A61P25/00 ,  C12N2750/1414320130101 ,  C12N15/86 ,  A61K48/005 ,  A61K38/00 ,  C07K14/4705

公开(公告)号：EP2608799B1

公开(公告)日：2018-12-12

申请号：EP11820530.1

申请日：2011-08-23

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： OKADA, Hideho

IPC分类号： A61K38/08 ,  A61K39/39 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/0011 ,  A61K9/0019 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/177 ,  A61K38/2086 ,  A61K39/39 ,  A61K2039/5154 ,  A61K2039/55566 ,  A61K2039/55583 ,  A61K2039/572 ,  A61K2039/70 ,  C07K14/4703 ,  C07K14/4705 ,  C07K14/705 ,  C07K14/7155 ,  A61K2300/00

摘要： Provided herein are interleukin-13 receptor α2 peptide-based brain cancer vaccines and methods for treating and vaccinating against brain cancer comprising administering to patients in need thereof interleukin-13 receptor α2 peptide-based brain cancer vaccines. Also provided herein are regimens comprising interleukin-13 receptor α2 peptides and at least one additional peptide and/or immunostimulant.

公开(公告)号：EP2751257B1

公开(公告)日：2018-06-27

申请号：EP12831715.3

申请日：2012-09-14

申请人： Ottawa Hospital Research Institute

发明人： RUDNICKI, Michael ,  BENTZINGER, Conrad Florian ,  ZINOVIEV, Radoslav

IPC分类号： C12N5/074 ,  C12N15/12 ,  A61K38/17 ,  C07K14/47 ,  A61K38/00 ,  C12N5/077

CPC分类号： C07K14/4705 ,  A61K38/00 ,  A61K38/1709 ,  A61K45/06 ,  A61K48/00 ,  C07K14/4702 ,  C07K14/4707 ,  C07K14/4708 ,  C12N5/0659 ,  C12N7/00 ,  C12N2501/415 ,  C12N2533/52 ,  C12N2710/10042 ,  C12N2740/10042 ,  C12N2740/15042

摘要： There are provided compositions and methods for modulating stem cell division, in particular, division symmetry. It has been demonstrated that Wnt7a polypeptide fragments promoting symmetrical expansion of stem cells. The compositions and methods of the invention are useful, for example, in modulating stem cell division symmetry in vitro, ex vivo, and in vivo, in replenishing and expanding the stem cell pool, and in promoting the formation, maintenance, repair and regeneration of tissue.

公开(公告)号：EP2703487B1

公开(公告)日：2018-06-27

申请号：EP12777041.0

申请日：2012-04-03

申请人： Genomix Co., Ltd. ,  Osaka University

发明人： TAMAI, Katsuto ,  YAMAZAKI, Takehiko ,  KANEZAKI, Tsutomu ,  SAKURAI, Shigeru ,  NOGUCHI, Yukiko ,  ENDO, Mayumi ,  HAMABUCHI, Natsumi ,  NAITO, Kana

IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K31/713 ,  A61K35/12 ,  A61K35/28 ,  A61K35/76 ,  A61K38/00 ,  A61K48/00 ,  A61P1/00 ,  A61P1/04 ,  A61P9/00 ,  A61P9/10 ,  A61P17/00 ,  A61P19/00 ,  A61P21/00 ,  C07K14/47 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10

CPC分类号： C07K14/4705 ,  A61K38/17 ,  C07K14/4702

摘要： (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFR±-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body. (Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFR±-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFR±-positive cells.

公开(公告)号：EP2828280B1

公开(公告)日：2018-05-02

申请号：EP13764023.1

申请日：2013-03-10

申请人： Ramot at Tel-Aviv University Ltd.

发明人： MOROZ, Chaya

IPC分类号： C07K4/12 ,  C07K14/52 ,  C07K16/24 ,  A61K38/19 ,  A61P31/18 ,  A61P35/02 ,  A61P37/04 ,  C07K14/47

CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/57 ,  A61K2039/58 ,  C07K7/08 ,  C07K14/001 ,  C07K14/47 ,  C07K14/4705 ,  C07K2319/00

摘要： Provided is a multimeric peptide comprising at least two peptide monomers linked to one another, each of the at least two peptide monomers comprising at least 6 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO: 1, wherein the at least two peptide monomers are each no longer than 30 amino acids, wherein the multimeric peptide is capable of reducing binding of Placenta Immunomodulatory Factor (PLIF) to human leukocytes.

公开(公告)号：EP3003350B1

公开(公告)日：2018-02-21

申请号：EP14728872.4

申请日：2014-05-27

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Rheinisch-Westfälische Technische Hochschule Aachen

发明人： THEPEN, Theophilus ,  HRISTODOROV, Dmitrij ,  MLADENOV, Radoslav ,  BARTH, Stefan

IPC分类号： A61K38/17 ,  C07K16/28 ,  C07K14/47

CPC分类号： C07K14/4705 ,  A61K38/177 ,  C07K16/28 ,  C07K2319/30 ,  C07K2319/33 ,  Y02A50/473

摘要： An immunomodulatory fusion protein (IFP) for converting pro-inflammatory M macrophages to anti-inflammatory M2 like phenotypes of macrophagesthe IFP having at least one component A and at least one component B wherein the component A is comprising or consisting of a binding domain for extra-cellular surface structures of a macrophage that internalizes said immunomodulatory fusion protein upon binding of component A of said immunomodulatory fusion protein, and the component B is modulating the macrophage and comprises or consists of a DNA oligonucleotide or RNA oligonucleotide or a chemical small molecule exhibiting modulatory functions to targeted macrophages or a polypeptide which amino acid sequence comprises or consists of a macrophage modulatory protein or comprises or consists of at least a partial sequence of the macrophage modulatory protein, the partial sequence having maintained the modulatory function of the macrophage modulatory protein.

公开(公告)号：EP3264891A1

公开(公告)日：2018-01-10

申请号：EP16759528.9

申请日：2016-03-03

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： GARRY, Daniel J. ,  GARRY, Mary G. ,  RASMUSSEN, Tara ,  KOYANO-NAKAGAWA, Naoko

IPC分类号： A01K67/00 ,  A01K67/027 ,  C12N15/00 ,  C12N15/09

CPC分类号： C07K14/4705 ,  A01K67/0271 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/075 ,  A01K2227/108 ,  A01K2267/025 ,  C12N15/09

摘要： Described herein is a method for producing a chimeric non-human animal expressing a human ETV2 gene comprising: a) generating an ETV2 null non-human animal cell, wherein both copies of the non-human ETV2 gene carry a mutation that prevents production of functional ETV2 protein in said non-human animal; b) creating an ETV2 null non-human blastocyst by somatic cell nuclear transfer comprising fusing a nucleus from said ETV2 null non-human animal cell of a) into an enucleated non-human oocyte and activating said oocyte to divide so as to form an ETV2 null non-human blastocyst; c) introducing human stem cells into the ETV2 null non-human blastocyst of b); and d) implanting said blastocyst from c) into a pseudopregnant surrogate non-human animal to generate a chimeric non-human animal expressing human ETV2.