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    GLYCOMIMETIC COMPOUNDS AS ANTI-INFECTIOUS AGAINST PATHOGENS LECTINS
    3.
    发明公开
    GLYCOMIMETIC COMPOUNDS AS ANTI-INFECTIOUS AGAINST PATHOGENS LECTINS 有权
    GLYCOMIMETISCHE化合物作为防抗致病性凝集素

    公开(公告)号：EP2649085A1

    公开(公告)日：2013-10-16

    申请号：EP10812804.2

    申请日：2010-12-10

    申请人： Centre National de la Recherche Scientifique CNRS ,  Université Claude Bernard Lyon 1

    发明人： IMBERTY, Anne ,  VIDAL, Sébastien ,  MATTHEWS, Susan ,  FAURE, Karine ,  GUERY, Benoit ,  CECIONI, Samy

    IPC分类号： C07H3/06 ,  C07H5/06 ,  A61K31/7028 ,  A61P31/04

    CPC分类号： C07H17/08 ,  C07H3/06 ,  C07H5/06 ,  C07H17/02

    摘要： The present invention relates to a calixarene-based glycosylated compound (I) having the formula : (I) wherein D is independently selected in the group comprising a –CH
    2 –group, an oxygen atom, a sulphur atom, a sulfinyl group or a sulfonyl group, E is independently selected in the group comprising a hydrogen, an alkyl having from 1 to 10 carbon atoms, an aryl having from 6 to 20 carbon atoms, a nitrogen dioxide group, an azide group, an amino group, a guanidinium group,a halogen atom, a –CH
    2 R group wherein R is a hydroxyl, a halogen, an amino group, a N(alkyl)
    2 group, a NH(alkyl) group, or E represents a –CO-R' wherein R' is a hydrogen atom, a hydroxyl group or an amino, B represents a A–C group wherein A is independently selected in the group comprising an oxygen atom, a sulfur atom, a NH group or a (CH
    2 )
    i group, i being an integer from 1 to 10, C is independently selected in the group comprising a hydrogen, an alkyl, an alkenyl, an alkynyl, or C is a group of formula (II). The present invention also relates to a pharmaceutical composition characterized in that it comprises the said calixarene-based glycosylated compound (I), in combination with pharmaceutically acceptable carriers or diluents. The present invention also relates to the use of the said calixarene-based glycosylated compound (I) or the said pharmaceutical composition, for the manufacture of a drug intended to prevent or treat bacterial infections from pathogens that use lectins in the first steps of infection.

    NOUVELLES LECTINES ET APPLICATIONS POUR LA DÉTECTION DE MARQUEURS D'ÉTATS PATHOLOGIQUES
    5.
    发明公开
    NOUVELLES LECTINES ET APPLICATIONS POUR LA DÉTECTION DE MARQUEURS D'ÉTATS PATHOLOGIQUES 审中-公开
    新型凝集素和应用用于检测标志物病理学

    公开(公告)号：EP3114487A1

    公开(公告)日：2017-01-11

    申请号：EP15711300.2

    申请日：2015-02-26

    申请人： Centre National de la Recherche Scientifique CNRS ,  Université Joseph Fourier

    发明人： IMBERTY, Anne ,  AUDFRAY, Aymeric ,  ARNAUD, Julie

    IPC分类号： G01N33/68 ,  A61K49/14 ,  A23J3/20

    CPC分类号： G01N33/68 ,  C07K14/4726 ,  G01N2333/4724 ,  G01N2440/38 ,  G01N2570/00

    摘要： Multimenic lectins having a β-propeller architecture, formed from monomer modules of approximately 30 to 60 amino acids, in which the binding sites to the glycans are situated on a given side of the proteins and the O-terminus and N-terminus ends of the peptide chains on the other side of the proteins, characterized in that they are formed from 4 to 7 monomer modules, a single, or a plurality of, or all of the adjacent modules being linked to one another by the linkers linking the N-terminus end of one module to the C-terminus end of the adjacent module.

    摘要翻译： 作为具有β螺旋桨结构，从大约30至60个氨基酸，其中该结合位点的聚糖都位于蛋白和O末端和N-末端的给定侧的单体模块构成Multimenic凝集素的结束 对蛋白质的另一侧的肽链，在thatthey特点是从4到7的单体模块，单个或多个形成，或所有相邻的模块被彼此连接由连接器连接的N末端 一个模块的相邻模块的C末端端的一端。