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    GLYCOMIMETIC COMPOUNDS AS ANTI-INFECTIOUS AGAINST PATHOGENS LECTINS
    3.
    发明公开
    GLYCOMIMETIC COMPOUNDS AS ANTI-INFECTIOUS AGAINST PATHOGENS LECTINS 有权
    GLYCOMIMETISCHE化合物作为防抗致病性凝集素

    公开(公告)号：EP2649085A1

    公开(公告)日：2013-10-16

    申请号：EP10812804.2

    申请日：2010-12-10

    申请人： Centre National de la Recherche Scientifique CNRS ,  Université Claude Bernard Lyon 1

    发明人： IMBERTY, Anne ,  VIDAL, Sébastien ,  MATTHEWS, Susan ,  FAURE, Karine ,  GUERY, Benoit ,  CECIONI, Samy

    IPC分类号： C07H3/06 ,  C07H5/06 ,  A61K31/7028 ,  A61P31/04

    CPC分类号： C07H17/08 ,  C07H3/06 ,  C07H5/06 ,  C07H17/02

    摘要： The present invention relates to a calixarene-based glycosylated compound (I) having the formula : (I) wherein D is independently selected in the group comprising a –CH
    2 –group, an oxygen atom, a sulphur atom, a sulfinyl group or a sulfonyl group, E is independently selected in the group comprising a hydrogen, an alkyl having from 1 to 10 carbon atoms, an aryl having from 6 to 20 carbon atoms, a nitrogen dioxide group, an azide group, an amino group, a guanidinium group,a halogen atom, a –CH
    2 R group wherein R is a hydroxyl, a halogen, an amino group, a N(alkyl)
    2 group, a NH(alkyl) group, or E represents a –CO-R' wherein R' is a hydrogen atom, a hydroxyl group or an amino, B represents a A–C group wherein A is independently selected in the group comprising an oxygen atom, a sulfur atom, a NH group or a (CH
    2 )
    i group, i being an integer from 1 to 10, C is independently selected in the group comprising a hydrogen, an alkyl, an alkenyl, an alkynyl, or C is a group of formula (II). The present invention also relates to a pharmaceutical composition characterized in that it comprises the said calixarene-based glycosylated compound (I), in combination with pharmaceutically acceptable carriers or diluents. The present invention also relates to the use of the said calixarene-based glycosylated compound (I) or the said pharmaceutical composition, for the manufacture of a drug intended to prevent or treat bacterial infections from pathogens that use lectins in the first steps of infection.