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    GROWTH-STIMULATING POLYPEPTIDES FOR USE IN FISH AND CRUSTACEANS
    2.
    发明公开
    GROWTH-STIMULATING POLYPEPTIDES FOR USE IN FISH AND CRUSTACEANS 有权
    WASSTUMSSTIMULIERENDE POLYPEPTIDE ZUR VERWENDUNG在FISCH UND SCHALENTIEREN

    公开(公告)号：EP1911764A1

    公开(公告)日：2008-04-16

    申请号：EP06753160.8

    申请日：2006-06-23

    申请人： CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA (CIGB)

    发明人： ACOSTA ALBA, Jannel ,  ESTRADA GARCÍA, Mario Pablo ,  CARPIO GONZÁLEZ, Yamila ,  MORALES FERNÁNDEZ, Reynold

    IPC分类号： C07K14/46 ,  C07K14/61 ,  C12P21/02 ,  A23K1/165

    CPC分类号： C07K14/61 ,  A23K20/147 ,  A23K50/80 ,  C07K14/461 ,  C12N15/81

    摘要： The present invention is related with polypeptides which show an increased activity compared with tilapia growth hormone. These polypeptides are able to stimulate growth, survival and the quality of fish and crustaceans larvae. Also, they increase the defences against pathogens and stimulate parameters related with the immune system of aquatic organisms. The polypeptides encoding genes were cloned into a Pichia pastoris expression vector. This vector allows the extracellular expression of the target proteins. The culture supernatants which contain the target polypeptides were administrated by immersion baths or as a feed additive to aquatic organisms.

    摘要翻译： 本发明涉及与罗非鱼生长激素相比显示增加的活性的多肽。 这些多肽能够刺激鱼和甲壳类动物幼虫的生长，存活和质量。 此外，它们增加对病原体的防御，并刺激与水生生物免疫系统相关的参数。 将编码基因的多肽克隆到巴斯德毕赤酵母表达载体中。 该载体允许靶蛋白的细胞外表达。 含有靶多肽的培养物上清液通过浸浴或作为饲料添加剂施用于水生生物体。

    AMINO ACID SEQUENCES FOR CONTROLLING PATHOGENS
    3.
    发明公开
    AMINO ACID SEQUENCES FOR CONTROLLING PATHOGENS 有权
    AMINOSÄURESEQUENZZUR KONTROLLE VON PATHOGENEN

    公开(公告)号：EP2767290A1

    公开(公告)日：2014-08-20

    申请号：EP12783080.0

    申请日：2012-10-01

    申请人： Centro De Ingenieria Genetica Y Biotecnologia

    发明人： ACOSTA ALBA, Jannel ,  ESTRADA GARCÍA, Mario, Pablo

    IPC分类号： A61K38/17 ,  C07K14/435

    CPC分类号： A61K39/39 ,  A23K20/147 ,  A61K38/00 ,  C07K14/461

    摘要： The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia ( Oreochromis niloticus ) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.

    摘要翻译： 本发明涉及从罗非鱼（Oreochromis niloticus）鳃提取物中分离和纯化的抗微生物肽。 这些肽可以通过化学合成或通过常规分子生物学技术在异源系统如细菌和酵母中表达来产生。 这些肽显示出对各种生物体的抗菌活性，包括革兰氏阳性菌，革兰氏阴性菌，真菌和病毒。 本发明还包括用于控制包含这些抗微生物肽的病原体的组合物。 疫苗制剂中作为分子佐剂使用这些肽也是本发明的一部分。