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1.发明公开COMPOUNDS AND PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND ISCHEMIC BRAIN DISEASES 有权物质和神经变性的治疗药物组合物和局部缺血性脑功能障碍
公开(公告)号：EP2733149A1
公开(公告)日：2014-05-21
申请号：EP12743356.3
申请日：2012-06-29
发明人： PENTON ROL, Giselle , LLOPIZ ARZUAGA, Alexey , MARÍN PRIDA, Javier , PENTÓN ARIAS, Eduardo , RODRÍGUEZ JIMÉNEZ, Efraín , MUSACCHIO LASA, Alexis , BESADA PÉREZ, Vladimir, Armando , PARDO ANDREU, Gilberto, Lázaro , GONZÁLEZ LÓPEZ, Luis, Javier , PAVÓN FUENTES, Nancy , GUILLÉN NIETO, Gerardo, Enrique , LÓPEZ SAURA, Pedro, Antonio
CPC分类号： A61K31/409 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/1816 , A61K38/2013 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/25 , A61K47/55 , C07K5/08 , C07K5/081 , C07K5/10 , C07K5/1008 , C07K7/06 , A61K2300/00 , A61K36/06
摘要： The present invention describes peptides comprising phycocyanobilin (PCB), as well as the medical use of said peptides and that of PCB, due to the neuroprotector and/or neuroregenerative effects identified for them. Furthermore, pharmaceutical combinations of said peptides and of PCB with proteins or other peptides with synergic effect justify their use for ischemic or neurodegenerative CNS disease treatment.
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2.发明公开METHOD FOR THE TREATMENT OF FLAVIVIRUS INFECTION, MOLECULES AND USES THEREOF 有权VERFAHREN ZUR BEHANDLUNG VON FLAVIVIRUS-INFEKTION，MOLEKÜLEUND IHRE VERWENDUNGEN
公开(公告)号：EP2022506A2
公开(公告)日：2009-02-11
申请号：EP07721810.5
申请日：2007-04-26
发明人： HUERTA GALINDO, Vivian , CHINEA SANTIAGO, Glay , FLEITAS SALAZAR, Noralvis , MARTÍN DUNN, Alejandro, Miguel , SARRÍA NÚÑEZ, Mónica , GUIROLA CRUZ, Osmany , TOLEDO MAYORA, Patricia, Gabriela , SÁNCHEZ PUENTE, Aniel , BESADA PÉREZ, Vladimir, Armando , REYES ACOSTA, Osvaldo , GARAY PÉREZ, Hilda, Elisa , CABRALES RICO, Ania , MUSACCHIO LASA, Alexis , PADRÓN PALOMARES, Gabriel, Ramón , GONZÁLEZ LÓPEZ, Luis, Javier
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 使用; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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公开(公告)号：EP2733149B9
公开(公告)日：2019-05-15
申请号：EP12743356.3
申请日：2012-06-29
发明人： PENTON ROL, Giselle , LLOPIZ ARZUAGA, Alexey , MARÍN PRIDA, Javier , PENTÓN ARIAS, Eduardo , RODRÍGUEZ JIMÉNEZ, Efraín , MUSACCHIO LASA, Alexis , BESADA PÉREZ, Vladimir, Armando , PARDO ANDREU, Gilberto, Lázaro , GONZÁLEZ LÓPEZ, Luis, Javier , PAVÓN FUENTES, Nancy , GUILLÉN NIETO, Gerardo, Enrique , LÓPEZ SAURA, Pedro, Antonio
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4.发明授权
公开(公告)号：EP2022506B1
公开(公告)日：2017-10-11
申请号：EP07721810.5
申请日：2007-04-26
发明人： HUERTA GALINDO, Vivian , CHINEA SANTIAGO, Glay , FLEITAS SALAZAR, Noralvis , MARTÍN DUNN, Alejandro, Miguel , SARRÍA NÚÑEZ, Mónica , GUIROLA CRUZ, Osmany , TOLEDO MAYORA, Patricia, Gabriela , SÁNCHEZ PUENTE, Aniel , BESADA PÉREZ, Vladimir, Armando , REYES ACOSTA, Osvaldo , GARAY PÉREZ, Hilda, Elisa , CABRALES RICO, Ania , MUSACCHIO LASA, Alexis , PADRÓN PALOMARES, Gabriel, Ramón , GONZÁLEZ LÓPEZ, Luis, Javier
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
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5.发明授权COMPOUNDS AND PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND ISCHEMIC BRAIN DISEASES 有权物质和神经变性的治疗药物组合物和局部缺血性脑功能障碍
公开(公告)号：EP2733149B1
公开(公告)日：2016-09-28
申请号：EP12743356.3
申请日：2012-06-29
发明人： PENTON ROL, Giselle , LLOPIZ ARZUAGA, Alexey , MARÍN PRIDA, Javier , PENTÓN ARIAS, Eduardo , RODRÍGUEZ JIMÉNEZ, Efraín , MUSACCHIO LASA, Alexis , BESADA PÉREZ, Vladimir, Armando , PARDO ANDREU, Gilberto, Lázaro , GONZÁLEZ LÓPEZ, Luis, Javier , PAVÓN FUENTES, Nancy , GUILLÉN NIETO, Gerardo, Enrique , LÓPEZ SAURA, Pedro, Antonio
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/20 , A61K38/21 , A61K38/25 , C07K5/083 , C07K5/103 , C07K7/06
CPC分类号： A61K31/409 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/1816 , A61K38/2013 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/25 , A61K47/55 , C07K5/08 , C07K5/081 , C07K5/10 , C07K5/1008 , C07K7/06 , A61K2300/00 , A61K36/06
摘要： The present invention describes peptides comprising phycocyanobilin (PCB), as well as the medical use of said peptides and that of PCB, due to the neuroprotector and/or neuroregenerative effects identified for them. Furthermore, pharmaceutical combinations of said peptides and of PCB with proteins or other peptides with synergic effect justify their use for ischemic or neurodegenerative CNS disease treatment.
摘要翻译： 本发明描述的肽，其包括藻蓝胆素（PCB），以及医疗使用所述肽的和做PCB的，由于神经保护和/或识别为他们的神经再生的影响。 进一步，所述肽和与PCB或其它肽与协同作用的蛋白质的药物组合证明自己的局部缺血或神经变性疾病的CNS治疗用途。
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