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1.发明授权CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES 有权具有抗登革热病毒和其他黄病毒的抗病毒活性的化学化合物
公开(公告)号：EP2258356B1
公开(公告)日：2017-09-27
申请号：EP09714439.8
申请日：2009-02-27
发明人： MAZOLA REYES, Yuliet , CHINEA SANTIAGO, Glay , GUIROLA CRUZ, Osmany , VERA ALVAREZ, Roberto , HUERTA GALINDO, Vivian , FLEITAS SALAZAR, Noralvis , MUSACCHIO LASA, Alexis
IPC分类号： A61K31/428 , A61K31/495 , A61K31/00 , A61K31/496 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K31/425 , A61K31/381 , A61K31/404 , A61K31/433 , A61K31/40 , A61K31/4192 , A61K31/34 , A61K31/505 , A61K31/55 , A61P31/14
CPC分类号： A61K31/16 , A61K31/18 , A61K31/381 , A61K31/41 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/535 , A61K31/55 , A61K47/54 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the modulation of several stages of viral replication cycle related with the entry of virus into host cells and the assembly of mature progeny virions. The invention also comprises the use of such pharmaceutical compositions for prophylactic and/or therapeutic treatment of infection caused by all four serotypes of Dengue virus and other flaviviruses.
摘要翻译： 利用计算机获得的化学化合物制备药物组合物以减轻或抑制登革热病毒感染。 特别是通过干扰或调节与病毒进入宿主细胞相关的几个病毒复制周期阶段和成熟后代病毒体的组装。 本发明还包括这些药物组合物用于预防性和/或治疗性治疗由所有四种登革病毒血清型和其他黄热病病毒引起的感染的用途。
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公开(公告)号：EP1892245A2
公开(公告)日：2008-02-27
申请号：EP06753157.4
申请日：2006-05-05
发明人： RODRIGUEZ FERNANDEZ, Rolando Eduardo , VERA ALVAREZ, Roberto , DE LA NUEZ VEULENS, Ania , MAZOLA REYES, Yuliet , PEREA RODRÍGUEZ, Silvio, Ernesto , ACEVEDO CASTRO, Boris Ernesto , MUSACCHIO LASA, Alexis , UBIETA GÓMEZ, Raimundo
IPC分类号： C07F9/22 , C07D487/04 , C07D239/42 , C07D239/36 , C07D233/54 , C07D235/14 , C07D215/18 , C07D213/82 , C07D207/36 , C07C237/30 , C07C327/44 , C07C313/06 , C07C275/36 , C07C275/22 , C07C275/18
CPC分类号： C07C211/14 , C07C237/06 , C07C237/22 , C07C243/28 , C07C255/42 , C07C257/14 , C07C271/22 , C07C271/64 , C07C275/08 , C07C275/16 , C07C275/24 , C07C281/12 , C07C317/28 , C07C327/42 , C07C337/08 , C07D207/34 , C07D209/14 , C07D213/81 , C07D213/82 , C07D215/46 , C07D233/88 , C07D233/91 , C07D235/14 , C07D239/36 , C07D239/46 , C07D239/54 , C07D251/22 , C07D307/52 , C07D487/04 , C07F9/224
摘要： Chemical compounds identified by in silico molecular modelling, and having an structure that allows the blocking of the phosphorylation event, through the interaction of such compounds with the phosphorylation domain or its milieu in the substrates of the Casein Kinase 2 enzyme. This invention comprises also the pharmaceutical compositions containing such compounds, and their use in the preparation of medicines for the treatment of diseases related with neoplasic processes.
摘要翻译： 化学化合物通过硅胶分子模拟鉴定，并具有允许阻断磷酸化事件的结构，通过这些化合物与酪蛋白激酶2酶底物中磷酸化结构域或其环境的相互作用。 本发明还包含含有这些化合物的药物组合物及其在制备用于治疗与新生物相关疾病的药物中的用途。
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3.发明授权
公开(公告)号：EP2022506B1
公开(公告)日：2017-10-11
申请号：EP07721810.5
申请日：2007-04-26
发明人： HUERTA GALINDO, Vivian , CHINEA SANTIAGO, Glay , FLEITAS SALAZAR, Noralvis , MARTÍN DUNN, Alejandro, Miguel , SARRÍA NÚÑEZ, Mónica , GUIROLA CRUZ, Osmany , TOLEDO MAYORA, Patricia, Gabriela , SÁNCHEZ PUENTE, Aniel , BESADA PÉREZ, Vladimir, Armando , REYES ACOSTA, Osvaldo , GARAY PÉREZ, Hilda, Elisa , CABRALES RICO, Ania , MUSACCHIO LASA, Alexis , PADRÓN PALOMARES, Gabriel, Ramón , GONZÁLEZ LÓPEZ, Luis, Javier
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
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4.发明授权COMPOUNDS AND PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND ISCHEMIC BRAIN DISEASES 有权物质和神经变性的治疗药物组合物和局部缺血性脑功能障碍
公开(公告)号：EP2733149B1
公开(公告)日：2016-09-28
申请号：EP12743356.3
申请日：2012-06-29
发明人： PENTON ROL, Giselle , LLOPIZ ARZUAGA, Alexey , MARÍN PRIDA, Javier , PENTÓN ARIAS, Eduardo , RODRÍGUEZ JIMÉNEZ, Efraín , MUSACCHIO LASA, Alexis , BESADA PÉREZ, Vladimir, Armando , PARDO ANDREU, Gilberto, Lázaro , GONZÁLEZ LÓPEZ, Luis, Javier , PAVÓN FUENTES, Nancy , GUILLÉN NIETO, Gerardo, Enrique , LÓPEZ SAURA, Pedro, Antonio
IPC分类号： A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/20 , A61K38/21 , A61K38/25 , C07K5/083 , C07K5/103 , C07K7/06
CPC分类号： A61K31/409 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/1816 , A61K38/2013 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/25 , A61K47/55 , C07K5/08 , C07K5/081 , C07K5/10 , C07K5/1008 , C07K7/06 , A61K2300/00 , A61K36/06
摘要： The present invention describes peptides comprising phycocyanobilin (PCB), as well as the medical use of said peptides and that of PCB, due to the neuroprotector and/or neuroregenerative effects identified for them. Furthermore, pharmaceutical combinations of said peptides and of PCB with proteins or other peptides with synergic effect justify their use for ischemic or neurodegenerative CNS disease treatment.
摘要翻译： 本发明描述的肽，其包括藻蓝胆素（PCB），以及医疗使用所述肽的和做PCB的，由于神经保护和/或识别为他们的神经再生的影响。 进一步，所述肽和与PCB或其它肽与协同作用的蛋白质的药物组合证明自己的局部缺血或神经变性疾病的CNS治疗用途。
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公开(公告)号：EP1785143B1
公开(公告)日：2015-03-04
申请号：EP05779477.8
申请日：2005-08-29
发明人： MUSACCHIO LASA, Alexis , DUEÑAS CARRERA, Santiago c/o Centro de Ingenieria Genética y Biotecnologia , ALVAREZ-LAJONCHERE PONCE DE LEÓN, Liz , ACOSTA RIVERO, Nelson General Lee, No. 201 altos , MARTÍNEZ DONATO, Gillian Calle 186 , GUIROLA TSIBULOVA, María Cervantes, No. 35 A , SARDIÑAS GARCÍA, Gretel Jorge, No. 18
CPC分类号： A61K39/095 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/555 , A61K2039/55505 , A61K2039/55566 , A61K2039/57 , A61K2039/70 , C12N2710/24143 , C12N2730/10134 , C12N2770/24234
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6.发明公开COMPOUNDS AND PHARMACEUTICAL COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND ISCHEMIC BRAIN DISEASES 有权物质和神经变性的治疗药物组合物和局部缺血性脑功能障碍
公开(公告)号：EP2733149A1
公开(公告)日：2014-05-21
申请号：EP12743356.3
申请日：2012-06-29
发明人： PENTON ROL, Giselle , LLOPIZ ARZUAGA, Alexey , MARÍN PRIDA, Javier , PENTÓN ARIAS, Eduardo , RODRÍGUEZ JIMÉNEZ, Efraín , MUSACCHIO LASA, Alexis , BESADA PÉREZ, Vladimir, Armando , PARDO ANDREU, Gilberto, Lázaro , GONZÁLEZ LÓPEZ, Luis, Javier , PAVÓN FUENTES, Nancy , GUILLÉN NIETO, Gerardo, Enrique , LÓPEZ SAURA, Pedro, Antonio
CPC分类号： A61K31/409 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/1816 , A61K38/2013 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/25 , A61K47/55 , C07K5/08 , C07K5/081 , C07K5/10 , C07K5/1008 , C07K7/06 , A61K2300/00 , A61K36/06
摘要： The present invention describes peptides comprising phycocyanobilin (PCB), as well as the medical use of said peptides and that of PCB, due to the neuroprotector and/or neuroregenerative effects identified for them. Furthermore, pharmaceutical combinations of said peptides and of PCB with proteins or other peptides with synergic effect justify their use for ischemic or neurodegenerative CNS disease treatment.
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7.发明公开METHOD FOR THE TREATMENT OF FLAVIVIRUS INFECTION, MOLECULES AND USES THEREOF 有权VERFAHREN ZUR BEHANDLUNG VON FLAVIVIRUS-INFEKTION，MOLEKÜLEUND IHRE VERWENDUNGEN
公开(公告)号：EP2022506A2
公开(公告)日：2009-02-11
申请号：EP07721810.5
申请日：2007-04-26
发明人： HUERTA GALINDO, Vivian , CHINEA SANTIAGO, Glay , FLEITAS SALAZAR, Noralvis , MARTÍN DUNN, Alejandro, Miguel , SARRÍA NÚÑEZ, Mónica , GUIROLA CRUZ, Osmany , TOLEDO MAYORA, Patricia, Gabriela , SÁNCHEZ PUENTE, Aniel , BESADA PÉREZ, Vladimir, Armando , REYES ACOSTA, Osvaldo , GARAY PÉREZ, Hilda, Elisa , CABRALES RICO, Ania , MUSACCHIO LASA, Alexis , PADRÓN PALOMARES, Gabriel, Ramón , GONZÁLEZ LÓPEZ, Luis, Javier
IPC分类号： A61K39/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 使用; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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8.发明公开COMPOUNDS ANALOGOUS TO GROWTH HORMONE PEPTIDE SECRETAGOGUES AND PREPARATIONS CONTAINING THEM 有权与生长激素肽类似物相容的化合物以及含有它们的制剂
公开(公告)号：EP1997827A1
公开(公告)日：2008-12-03
申请号：EP07711101.1
申请日：2007-02-28
发明人： RODRIGUEZ FERNANDEZ, Rolando, Eduardo , DE LA NUEZ VEULENS, Ania , ESTRADA GARCÍA, Mario, Pablo , MARTÍNEZ RODRÍGUEZ, Rebeca , CHINEA SANTIAGO, Glay , REYES ACOSTA, Osvaldo , FERNÁNDEZ MASSÓ, Julio, Raúl , GARCÍA DEL BARCO HERRERA, Diana , BERLANGA ACOSTA, Jorge, Amador , MUSACCHIO LASA, Alexis
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过计算机模拟分子模型获得的肽化学化合物，具有使它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养增补剂或其它人或动物用途制剂中的用途。
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公开(公告)号：EP1029549A1
公开(公告)日：2000-08-23
申请号：EP99942707.3
申请日：1999-09-03
发明人： AGUILAR RUBIDO, Julio César , MUZIO GONZALEZ, Verena Lucila , GUILLEN NIETO, Gerardo Enrique , PENTON ARIAS, Eduardo , LEAL ANGULO, Maria de Jesús , PICHARDO DIAZ, Dagmara Calle 222 No. 2716 , IGLESIAS PEREZ, Enrique Edificio 25 Apto. 103 , HERRERA BUCH, Antonieta , SANDEZ OQUENDO, Bélquis , MUSACCHIO LASA, Alexis , QUINTANA VAZQUEZ, Diógenes , CROMBET MENENDEZ, Lissete
CPC分类号： A61K39/21 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55583 , C12N2740/16034
摘要： The present invention is related to the medical field, and in particular to the use of new formulations of adjuvants with vaccine antigens. The technical object of the invention is the development of formulations which are capable of potentiating the immune response of the organism to vaccines of nucleic acids. In order to attain this objective, a formulation has been developed which contains as fundamental components the vaccine nucleic acid and acemannan in adequate proportions, in addition to stabilizing and preservative agents. The formulations of the invention are applicable to the pharmaceutical industry as vaccine formulations both for human and animal use.
摘要翻译： 本发明涉及医疗领域，特别涉及使用具有疫苗抗原的佐剂的新制剂。 本发明的技术目的是开发能够增强生物体对核酸疫苗的免疫应答的制剂。 为了达到这个目标，除了稳定剂和防腐剂之外，已经开发出一种配方，其中含有足够比例的疫苗核酸和acemannan作为基本组分。 本发明的制剂适用于作为用于人类和动物使用的疫苗制剂的制药工业。
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10.发明授权
公开(公告)号：EP2733149B9
公开(公告)日：2019-05-15
申请号：EP12743356.3
申请日：2012-06-29
发明人： PENTON ROL, Giselle , LLOPIZ ARZUAGA, Alexey , MARÍN PRIDA, Javier , PENTÓN ARIAS, Eduardo , RODRÍGUEZ JIMÉNEZ, Efraín , MUSACCHIO LASA, Alexis , BESADA PÉREZ, Vladimir, Armando , PARDO ANDREU, Gilberto, Lázaro , GONZÁLEZ LÓPEZ, Luis, Javier , PAVÓN FUENTES, Nancy , GUILLÉN NIETO, Gerardo, Enrique , LÓPEZ SAURA, Pedro, Antonio
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