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1.发明授权SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 有权取代的螺环哌啶衍生物比组胺-3（H 3）受体的配体
公开(公告)号：EP2250176B1
公开(公告)日：2012-08-01
申请号：EP09707104.7
申请日：2009-01-30
申请人： Cephalon, Inc. , Pharmacopeia, LLC
发明人： BACON, Edward, R. , DANDU, Reddeppareddy , GUISE-ZAWACKI, Lisa , HUANG, Chia-yu , HUDKINS, Robert, L. , TAO, Ming
IPC分类号： C07D491/10 , A61K31/438 , A61P25/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
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2.发明授权3,4-dihydro-2H-benzo[1,4]oxazine and 3,4-dihydro-2H-benzo[1,4]thiazine COMPOUNDS AS ALPHA2C ADRENORECEPTOR AGONISTS 有权3,4-二氢-2H-苯并[1,4]恶嗪和3,4-二氢-2H-苯并[1,4]噻嗪化合物作为alpha2C阻断剂
公开(公告)号：EP1934203B1
公开(公告)日：2010-08-18
申请号：EP06802156.7
申请日：2006-08-23
发明人： MCCORMICK, Kevin, D. , BOYCE, Christopher, W. , SHIH, Neng-Yang , ASLANIAN, Robert, G. , MANGIARACINA, Pietro , DE LERA RUIZ, Manuel , YU, Younong , BIJU, Purakkattle, J. , HUANG, Chia-Yu , LIANG, Bo , LIU, Ruiyan , LIU, Rong-Qiang , GUISE-ZAWACKI, Lisa
IPC分类号： C07D403/06 , C07D413/06 , C07D417/06 , A61K31/435 , A61K31/41 , A61P29/00
CPC分类号： C07D413/06 , C07D403/06 , C07D413/04 , C07D413/14 , C07D417/06 , C07D471/04 , C07D487/04 , C07D498/04
摘要： In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as a2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the a2C adrenergic receptor agonists using such compounds or pharmaceutical compositions.
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3.发明公开SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 有权取代的螺环哌啶衍生物作为组胺-3（H3）受体配体
公开(公告)号：EP2250176A1
公开(公告)日：2010-11-17
申请号：EP09707104.7
申请日：2009-01-30
申请人： Cephalon, Inc. , Pharmacopeia, Inc.
发明人： BACON, Edward, R. , DANDU, Reddeppareddy , GUISE-ZAWACKI, Lisa , HUANG, Chia-yu , HUDKINS, Robert, L. , TAO, Ming
IPC分类号： C07D491/10 , A61K31/438 , A61P25/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译： 本发明提供了式（I）的化合物：它们作为H3拮抗剂/反向激动剂的用途，它们的制备方法，以及它们的药物组合物。
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