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1.发明公开SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 有权取代的螺环哌啶衍生物作为组胺-3（H3）受体配体
公开(公告)号：EP2250176A1
公开(公告)日：2010-11-17
申请号：EP09707104.7
申请日：2009-01-30
申请人： Cephalon, Inc. , Pharmacopeia, Inc.
发明人： BACON, Edward, R. , DANDU, Reddeppareddy , GUISE-ZAWACKI, Lisa , HUANG, Chia-yu , HUDKINS, Robert, L. , TAO, Ming
IPC分类号： C07D491/10 , A61K31/438 , A61P25/00
CPC分类号： C07D491/10
摘要： The present invention provides compounds of Formula (I): their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceuticals compositions thereof.
摘要翻译： 本发明提供了式（I）的化合物：它们作为H3拮抗剂/反向激动剂的用途，它们的制备方法，以及它们的药物组合物。
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公开(公告)号：EP2069312B1
公开(公告)日：2012-11-07
申请号：EP07810758.8
申请日：2007-07-25
申请人： Cephalon, Inc.
发明人： HUDKINS, Robert, L. , JOSEF, Kurt, A. , TAO, Ming , BECKNELL, Nadine, C. , HOSTETLER, Greg , KNUTSEN, Lars, J., S. , ZULLI, Allison, L.
IPC分类号： C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D403/04 , C07D403/12 , C07D495/04 , A61K31/501 , A61K31/502 , A61K31/5025 , A61P25/28
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
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3.发明公开BENZOTHIAZO AND RELATED HETEROCYCLIC GROUP-CONTAINING CYSTEINE AND SERINE PROTEASE INHIBITORS 失效BENZOTHIAZOLO-和相关的杂环基团含半胱氨酸和丝氨酸蛋白酶抑制剂
公开(公告)号：EP0938477A1
公开(公告)日：1999-09-01
申请号：EP97949430.0
申请日：1997-11-13
申请人： CEPHALON, INC.
发明人： BIHOVSKY, Ron , WELLS, Gregory, J. , TAO, Ming
IPC分类号： A61K31 , A61P3 , A61P9 , A61P19 , A61P21 , A61P25 , A61P29 , A61P35 , A61P43 , C07D217 , C07D279 , C07D285 , C07D327 , C07D513 , C07D521 , C07F9
CPC分类号： C07D231/12 , C07D217/26 , C07D233/56 , C07D249/08 , C07D279/02 , C07D285/24 , C07D327/06 , C07D513/04 , C07F9/6547
摘要： The present invention is directed to novel benzothiazo and related heterocyclic group-containing inhibitors of cysteine or serine proteases. Methods for using the same are also described.
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公开(公告)号：EP2069312A2
公开(公告)日：2009-06-17
申请号：EP07810758.8
申请日：2007-07-25
申请人： Cephalon, Inc.
发明人： HUDKINS, Robert, L. , JOSEF, Kurt, A. , TAO, Ming , BECKNELL, Nadine, C. , HOSTETLER, Greg , KNUTSON, Lars, J., S. , ZULLI, Allison, L.
IPC分类号： C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D403/04 , C07D403/12 , C07D495/04 , A61K31/501 , A61K31/502 , A61K31/5025 , A61P25/28
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention provides compounds of formula (I*): their use as H3 inhibitors, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供了式（I *）的化合物：其作为H3抑制剂的用途，其制备方法及其药物组合物。
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公开(公告)号：EP0871454B1
公开(公告)日：2003-11-12
申请号：EP96923756.9
申请日：1996-07-12
申请人： CEPHALON, INC.
IPC分类号： A61K31/66 , A61K31/665 , A61K31/675 , C07F9/09 , C07F9/6574 , C07K5/06
CPC分类号： C07F9/091 , A61K38/00 , C07F9/3211 , C07F9/3252 , C07F9/3264 , C07F9/4006 , C07F9/4065 , C07F9/4075 , C07F9/5721 , C07F9/6533 , C07F9/657163 , C07F9/65742 , C07K5/06191
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公开(公告)号：EP1704148B1
公开(公告)日：2011-03-02
申请号：EP04815262.3
申请日：2004-12-23
申请人： CEPHALON, INC.
发明人： BECKNELL, Nadine, C. , DIEBOLD, James, L. , GINGRICH, Diane, E. , HUDKINS, Robert, L. , REDDY, Dandu, R. , TAO, Ming , UNDERINER, Theodore, L. , ZULLI, Allison, L.
IPC分类号： C07D487/04 , C07D487/14 , A61K31/407 , A61P35/00
CPC分类号： C07D487/14 , C07D487/04
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
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公开(公告)号：EP1711499B1
公开(公告)日：2009-06-10
申请号：EP04820922.5
申请日：2004-12-23
申请人： CEPHALON, INC.
发明人： HUDKINS, Robert, L. , REDDY, Dandu, R. , TAO, Ming , UNDERINER, Theodore, L. , ZULLI, Allison, L.
IPC分类号： C07D487/04 , C07D487/14 , C07D513/14 , A61K31/403 , A61K31/407 , A61P35/00
CPC分类号： C07D487/14 , C07D487/04 , C07D513/14 , C09B57/00 , C09B57/08
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
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公开(公告)号：EP1711499A2
公开(公告)日：2006-10-18
申请号：EP04820922.5
申请日：2004-12-23
申请人： CEPHALON, INC.
发明人： HUDKINS, Robert, L. , REDDY, Dandu, R. , TAO, Ming , UNDERINER, Theodore, L. , ZULLI, Allison, L.
IPC分类号： C07D487/04 , C07D487/14 , C07D513/14 , A61K31/403 , A61K31/407 , A61P35/00
CPC分类号： C07D487/14 , C07D487/04 , C07D513/14 , C09B57/00 , C09B57/08
摘要： The present invention relates generally to selected fused pyrrolocarbazoles, including pharmaceutical compositions thereof and methods of treating diseases therewith. The present invention is also directed to intermediates and processes for making these fused pyrrolocarbazoles.
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9.发明公开PEPTIDYL-2-AMINO-1-HYDROXYALKANESULFONIC ACID CYSTEINE PROTEASE INHIBITORS 失效肽2-氨基1HYDROXYALKANSULFONSÄURENALS半胱氨酸蛋白酶抑制剂
公开(公告)号：EP0975353A1
公开(公告)日：2000-02-02
申请号：EP98915572.6
申请日：1998-04-15
申请人： CEPHALON, INC.
发明人： BIHOVSKY, Ron , TAO, Ming
IPC分类号： A61K38/06
CPC分类号： C07K5/06043 , A61K38/00 , C07C309/24 , C07C311/19 , C07C2601/08 , C07D217/26 , C07K5/022 , C07K5/06026 , C07K5/06078
摘要： The present invention is directed to novel peptidyl-2-amino-1-hydroxyalkanesulfonic acid inhibitors of cysteine proteases. Methods for the use of the protease inhibitors are also described.
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公开(公告)号：EP0871454A1
公开(公告)日：1998-10-21
申请号：EP96923756.0
申请日：1996-07-12
申请人： CEPHALON, INC.
CPC分类号： C07F9/091 , A61K38/00 , C07F9/3211 , C07F9/3252 , C07F9/3264 , C07F9/4006 , C07F9/4065 , C07F9/4075 , C07F9/5721 , C07F9/6533 , C07F9/657163 , C07F9/65742 , C07K5/06191
摘要： The present invention is directed to novel phosphorous-containing inhibitors of cysteine or serine proteases. Methods for the use of the protease inhibitors are also described.
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