公开(公告)号：EP2616065A1

公开(公告)日：2013-07-24

申请号：EP11869827.3

申请日：2011-07-22

申请人： Biolitec Pharma Marketing Ltd ,  CeramOptec GmbH

发明人： AICHER, Daniel ,  ALBRECHT, Volker ,  GITTER, Burkhard ,  STARK, Christian, B. W. ,  WIEHE, Arno

IPC分类号： A61K31/409 ,  A61K31/19 ,  A61K31/185 ,  A61P31/04 ,  A61P31/00

CPC分类号： A61K31/185 ,  A61K31/19 ,  A61K31/409 ,  A61K31/7056 ,  A61K41/0071 ,  A61K47/549 ,  C07H15/26

摘要： Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The conjugates are of the class of compounds of dihydroxychlorins or &bgr;-functionalized chlorins connected to carbohydrate moieties and having the general formula

摘要翻译： 提供了用于治疗和预防人和动物中致病微生物引起的感染性疾病的抗微生物分子缀合物。 缀合物是与碳水化合物部分连接的二羟基二氢卟酚或二官能化二氢卟酚的化合物类，并具有通式

公开(公告)号：EP1701726A2

公开(公告)日：2006-09-20

申请号：EP04782618.5

申请日：2004-08-30

申请人： CeramOptec GmbH

发明人： ALBRECHT, Volker ,  GITTER, Burkhard

IPC分类号： A61K31/495 ,  A61K31/50 ,  A61P31/04

CPC分类号： A61K41/0019 ,  A61K41/0057 ,  A61N5/062

摘要： A method and composition for destroying microbes, especially bacteria, in the body utilizing Safranin O in conjunction with electromagnetic radiation is disclosed. In a preferred method, a composition comprising Safranin O is introduced to a treatment area. After a sufficient period of time has elapsed, radiation of a suitable wavelength is applied to the area to activate the Safranin O and by a photodynamic reaction to destroy the bacteria. Preferred radiation has a wavelength around 530 nm. This method is effective for destroying both Gram-positive and Gram-negative bacteria, and is particularly effective in areas where complex media such as blood serum, blood or saliva are also present.

公开(公告)号：EP1778294A2

公开(公告)日：2007-05-02

申请号：EP04783086.4

申请日：2004-09-03

申请人： CeramOptec GmbH

发明人： ALBRECHT, Volker ,  GITTER, Burkhard

IPC分类号： A61K48/00

CPC分类号： A61K9/0063 ,  A61K31/366 ,  A61K41/0057 ,  A61N5/062

摘要： A method and composition for destroying microbes, especially bacteria, in the body utilizing Erythrosin B in conjunction with electromagnetic radiation is disclosed. In a preferred method, a composition comprising Erythrosin B is introduced to a treatment area. After a sufficient period of time has elapsed, radiation of a suitable wavelength is applied to the area to activate the Erythrosin B and by a photodynamic reaction to destroy the bacteria. Preferred radiation has a wavelength around 530 nm. Erythrosin B is incorporated within a gel, which acts to restrict the photodynamic action proximate to the biofilm, thus ensuring that only unwanted bacteria is effected and natural microflora is unharmed. This method is effective for destroying at least Grampositive bacteria, and is particularly effective in areas where complex media such as saliva are also present.

公开(公告)号：EP2049105A2

公开(公告)日：2009-04-22

申请号：EP07797049.9

申请日：2007-07-27

申请人： CeramOptec GmbH

发明人： NIFANTIEV, Nikolay, E. ,  GITTER, Burkhard ,  YASHUNSKY, Dmitri, V.

IPC分类号： A61K31/407 ,  A61N5/00 ,  A61P31/04

CPC分类号： A61K31/407 ,  A61K41/0071 ,  A61K47/64

摘要： Antimicrobial molecular conjugates for the treatment and prevention of infectious diseases caused by pathogenic microorganisms in human and animals are provided. The key to these conjugates is a special spacer connecting at least one photosensitizer to a microorganism receptor (vector) which in turn binds selectively to the surface of a microorganism bringing about photo-destruction upon irradiation. Spacers having hydrophilic structure such as ethylene glycol units and amino carboxyl end capped ethylene glycol units must be used for linking the vector to the photosensitizer. In a preferred embodiment a spacer would have at least 3 ethylene glycol units and be end capped with a carboxyl group on one end and a amino group at the other end. The present invention effectively works to combat bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or at least nearby, of selected length and structure, in preferred embodiments, are used for linking the vector to the photosensitizer. These conjugate are found to be very effective in combating bacterial infection in the real patient-related environments where blood, serum and other body fluids are always present or a least nearby. A method of use is also provided.

公开(公告)号：EP2542305A2

公开(公告)日：2013-01-09

申请号：EP11735020.7

申请日：2011-01-13

申请人： CeramOptec GmbH

发明人： ALBRECHT, Volker ,  WIELAND, Gerhard ,  GITTER, Burkhard ,  NEUBERGER, Wolfgang

IPC分类号： A61N5/00 ,  A61N5/06 ,  A61K31/407 ,  A61P31/04

CPC分类号： A61N5/062 ,  A61L2/0029 ,  A61L2/0052 ,  A61L2202/21 ,  A61M1/3681 ,  A61M1/3686 ,  A61N5/0624 ,  A61N2005/063 ,  A61N2005/0652

摘要： Present invention provides enhanced methods and improved devices to eliminate, reduce, destroy and/or inhibit undesired body fluid species, such as pathogen microbes and deteriorated or malignant cells in complex environments like blood, serum and other body fluids. In preferred embodiments, present invention provides an antimicrobial PDT treatment that effectively inactivates, reduces and/or destroys both Gram (−) and Gram (+) bacteria in complex body fluids. Methods to enhance antimicrobial PDT activity includes the steps of administering a photosensitizer to bacteria-contaminated fluid, after a dwell time guiding bacteria-contaminated fluid with photosensitizer through a channel, emitting radiation preferably in an intermittent manner, and restoring treated body fluids to corresponding body regions. Electromagnetic radiation is preferably delivered intermittently with pulse width based on treatment parameters. Preferred device embodiments comprise guiding channels and at least one electromagnetic radiation source, arranged separately or in sequence. Preferably, laser device or LED-panels are used to deliver electromagnetic radiation to activate the photosensitizer. When used with preferred photosensitizer composition based on Safranin O, preferred laser radiation wavelength is in the range of 500-580 nm. Additionally, present invention diminishes adverse host's inflammatory responses by neutralizing the biological activity of pathogenic microorganism fragments and reducing and/or removing pathogenic microorganism fragments responsible for it.

摘要翻译： 本发明提供了增强的方法和改进的装置，以消除，减少，破坏和/或抑制诸如血液，血清和其他体液等复杂环境中的病原体微生物和恶化或恶性细胞等不希望的体液物质。 在优选实施方案中，本发明提供了一种抗微生物PDT治疗，其有效地灭活，减少和/或破坏复杂体液中的革兰氏阴性细菌和革兰氏阳性细菌。 增强抗微生物PDT活性的方法包括以下步骤：在用光敏剂引导细菌污染的流体通过通道，优选以间歇方式发射辐射并将经处理的体液恢复至相应的身体的驻留时间之后，将光敏剂施用于细菌污染的流体 区域。 电磁辐射优选基于治疗参数以脉冲宽度间歇地传递。 优选的设备实施例包括分开或依次布置的引导通道和至少一个电磁辐射源。 优选地，使用激光装置或LED面板来传递电磁辐射以激活光敏剂。 当与基于番红O的优选光敏剂组合物一起使用时，优选的激光辐射波长在500-580nm的范围内。 此外，本发明通过中和致病微生物片段的生物学活性并减少和/或去除对其有害的致病微生物片段来减少不利的宿主炎症反应。

公开(公告)号：EP1324663A1

公开(公告)日：2003-07-09

申请号：EP01966064.6

申请日：2001-08-22

申请人： CeramOptec GmbH

发明人： RIESENBERG, Dieter ,  SCHROECKH, Volker ,  GITTER, Burkhard ,  NEUBERGER, Wolfgang

IPC分类号： A01N61/00 ,  G01N33/53 ,  G01N33/569 ,  C07K14/195 ,  C07K16/12

CPC分类号： A61K31/00

摘要： A new approach for targeting chemotherapeutics to focal bacterial infections is provided. Such focal infections are characterized by high densities of different bacteria and thus high concentrations of their extracellular signal molecules sensing the cell density. In gram-negative bacteria, one of such signal molecules is acylhomoserine lactone (acyl-HSL, member of the autoinducer family AI-1), wherein species-specificity is achieved by acyl-residues, and HSLs are common for all gram-negative bacteria. In gram-positive bacteria, oligopeptides secreted by the bacteria communicate the cell density. In addition, there are cell density signal molecules (members of the autoinducer family AI-2) which communicate between gram-positive and gram-negative bacteria. The general scheme of the present invention is molecular modules that comprise both a targeting component and a chemotherapeutical component which serves for photodynamic antimicrobial chemotherapy (PACT). One preferred embodiment of the present invention is to target photosensitizers to the extracellular signal molecules instead of on the bacteria themselves. Targeting of the photosensitizers is mediated via molecules with efficient binding to the HSL-moiety of the acyl-HSL, so that a broad spectrum of gram-negative bacteria can be knocked out. Photosensitizers used in the present invention can be packed into special liposomes with lipid chelators or multiple coupled to dendrimers, so that they are especially effective for PACT. In addition, selected molecules with high affinity to a common moiety of such signal molecules, like HSL, may be used as molecular probes for the search of yet undiscovered cell density dependent signals.