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1.发明公开A method for the production of pharmaceutically active recombinant proteins comprising the use of alkanoic acids, their derivatives or salts thereof 有权一种用于药物活性的重组蛋白的，包括使用的链烷酸，其衍生物或其盐的制备方法
公开(公告)号：EP1245681A3
公开(公告)日：2003-12-03
申请号：EP02005935.8
申请日：2002-03-15
申请人： Cerbios-Pharma S.A.
发明人： Arini, Achille , Coppolecchia, Raffaella , Pagani, Francesca, Paola , Herbst, Detlev , Tognini, Antonio
CPC分类号： C12Y304/21073 , A61K38/00 , C12N9/6462 , C12N2500/36 , C12N2510/02
摘要： The present invention discloses a method for the production of a mature recombinant protein into the culture medium of an eukaryotic cell line genetically transfected with a cloned precursor cDNA sequence, which comprises an incubation of said cell line in the cell culture medium wherein alkanoic acids, their derivatives or salts thereof have been added for a period of time of at least 24 hours. The process allows the secretion of recombinant proteins into the culture medium in their physiologically active (mature) form.
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2.发明公开
公开(公告)号：EP1245681A2
公开(公告)日：2002-10-02
申请号：EP02005935.8
申请日：2002-03-15
申请人： Cerbios-Pharma S.A.
发明人： Arini, Achille , Coppolecchia, Raffaella , Pagani, Francesca, Paola , Herbst, Detlev , Tognini, Antonio
CPC分类号： C12Y304/21073 , A61K38/00 , C12N9/6462 , C12N2500/36 , C12N2510/02
摘要： The present invention discloses a method for the production of a mature recombinant protein into the culture medium of an eukaryotic cell line genetically transfected with a cloned precursor cDNA sequence, which comprises an incubation of said cell line in the cell culture medium wherein alkanoic acids, their derivatives or salts thereof have been added for a period of time of at least 24 hours. The process allows the secretion of recombinant proteins into the culture medium in their physiologically active (mature) form.
摘要翻译： 本发明盘松的方法用于生产成熟重组蛋白与克隆的前体的cDNA序列，在细胞培养基中所述的细胞系worin链烷酸的孵育，其包括，基因转染的真核细胞系的培养基中他们 其已被添加了一段的至少24小时的时间的衍生物或盐。 该方法允许重组蛋白的分泌到它们的生理学活性（成熟）形式培养基中。
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3.发明授权A method for the production of pharmaceutically active recombinant urokinase comprising the use of butyric acid or its salts 有权一种用于药物活性，重组尿激酶，包括使用的丁酸或它们的盐的制备方法
公开(公告)号：EP1245681B1
公开(公告)日：2007-06-06
申请号：EP02005935.8
申请日：2002-03-15
申请人： Cerbios-Pharma S.A.
发明人： Arini, Achille , Coppolecchia, Raffaella , Pagani, Francesca, Paola , Herbst, Detlev , Tognini, Antonio
CPC分类号： C12Y304/21073 , A61K38/00 , C12N9/6462 , C12N2500/36 , C12N2510/02
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