公开(公告)号：EP0187547A3

公开(公告)日：1987-07-22

申请号：EP85309560

申请日：1985-12-31

申请人： Ceskoslovenska akademie ved ,  CARLTON MEDICAL PRODUCTS LIMITED

发明人： Kopecek, Jindrich The Institute of ,  Rejmanova, Pavla The Institute of ,  Strohalm, Jiri The Institute of ,  Ulbrich, Karel The Institute of ,  Rihova, Blanka The Institute of ,  Chytry, Vladimir The Institute of ,  Lloyd, John B. Department of Biological Sciences ,  Duncan, Ruth Department of Biological Sciences

IPC分类号： A61K31/00 ,  A61K47/00

CPC分类号： A61K47/6883 ,  A61K47/58 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

摘要： A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moiety, and an optional cross-linkage, comprises:
(a) 5.0 to 99.7 mol % of units derived from N-(2-hydroxypropyl) methacrylamide, (b) 0.2 to 20.0 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a bioactive moiety, (c) 0.1 to 94.8 mol % of units derived from N-methacrylamide, N-methacrylic acid or an N-meth- ecryloylated aminoacid or peptide, to which are bound a determinant capable of interacting with specific receptors on cell surfaces, (d) optionally, 0 to 5 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a linking group which is similarly attached to a similar peptide group attached to another polymer chain, and (e) optionally, as a bioassay label, Q to 2 mol % of units derived from N-methacryloylated tyrosinamide.