公开(公告)号：EP0111386A3

公开(公告)日：1985-06-12

申请号：EP83306402

申请日：1983-10-21

申请人： UNIVERSITY OF ABERDEEN ,  CARLTON MEDICAL PRODUCTS LIMITED

发明人： Hynynen, Kulevro ,  Mallard, John Roland ,  Watmough, David John

IPC分类号： A61F07/00

CPC分类号： A61N7/02 ,  A61B2017/00084 ,  A61B2017/22028

摘要： An ultrasound unit for the clinical application of hyperthermia to tumour cells in soft tissues is provided. The ultrasound hyperthermic unit includes in one aspect an array of sonic transducers (1) radially disposed about an axis and angled to direct sonic energy (12) towards said axis at a point remote from said array, each transducer being adapted for angular movement relative to the other transducers thereby to allow adjustment of the shape of the acoustic focus. The array is computer controlled both with regard to acoustic focus and with regard to the energy imparted by each member of the array, said control being mediated by temperature sensing means (40) adjacent a tumour. This ultrasound unit may be associated with a heat treatment tank (51, 31) including a flexible membrane (32, 52) which may overlie a tumour, thereby to locally raise the temperature and reduce the amount of ultrasonic power required to achieve a desired temperature. Suitable adjustment of the focused energy raises the temperature of the tumour cells above viability, whereas the same energy density applied to healthy cells still allows viability by virtue of the relatively greater heat dissipation ability, and the geometric properties of a single focused transducer, or a multiply focused array.

公开(公告)号：EP0187547A3

公开(公告)日：1987-07-22

申请号：EP85309560

申请日：1985-12-31

申请人： Ceskoslovenska akademie ved ,  CARLTON MEDICAL PRODUCTS LIMITED

发明人： Kopecek, Jindrich The Institute of ,  Rejmanova, Pavla The Institute of ,  Strohalm, Jiri The Institute of ,  Ulbrich, Karel The Institute of ,  Rihova, Blanka The Institute of ,  Chytry, Vladimir The Institute of ,  Lloyd, John B. Department of Biological Sciences ,  Duncan, Ruth Department of Biological Sciences

IPC分类号： A61K31/00 ,  A61K47/00

CPC分类号： A61K47/6883 ,  A61K47/58 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

摘要： A polymeric drug comprising an inert synthetic polymeric carrier combined through aminoacid or peptide spacers with a bioactive molecule, a targeting moiety, and an optional cross-linkage, comprises:
(a) 5.0 to 99.7 mol % of units derived from N-(2-hydroxypropyl) methacrylamide, (b) 0.2 to 20.0 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a bioactive moiety, (c) 0.1 to 94.8 mol % of units derived from N-methacrylamide, N-methacrylic acid or an N-meth- ecryloylated aminoacid or peptide, to which are bound a determinant capable of interacting with specific receptors on cell surfaces, (d) optionally, 0 to 5 mol % of units derived from an N-methacryloylated peptide, the peptide groups being bound to a linking group which is similarly attached to a similar peptide group attached to another polymer chain, and (e) optionally, as a bioassay label, Q to 2 mol % of units derived from N-methacryloylated tyrosinamide.