公开(公告)号：EP1224222A2

公开(公告)日：2002-07-24

申请号：EP00973455.9

申请日：2000-10-10

申请人： Chemocentryx, Inc.

发明人： GOSLING, Jennifa ,  DAIRAGHI, Daniel, J. ,  HANLEY, Michael ,  MIAO, Zhenhua ,  TALBOT, Dale ,  SCHALL, Thomas, J.

IPC分类号： C07K14/705

CPC分类号： C07K14/7158 ,  C07K14/521 ,  C07K2319/00 ,  G01N33/5088 ,  G01N33/531 ,  G01N33/6863 ,  G01N2500/00

摘要： The invention provides polypeptides and polynucleotides encoding a novel chemokine receptor, CCX CKR. The invention further provides reagents and methods for identifying agents that modulate the activity or expression of the receptors, as well as methods for detecting receptor expression.

公开(公告)号：EP1274454A2

公开(公告)日：2003-01-15

申请号：EP01930632.3

申请日：2001-04-20

申请人： Chemocentryx, Inc.

发明人： SCHALL, Thomas, J. ,  TALBOT, Dale

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K38/00 ,  A61K2039/55522

摘要： The invention provides methods and compositions useful for inducing or enhancing an immune response in a human or non-human animal. In an embodiment, the method involves administering an antigen-presenting cell chemotaxin, such as a chemokine polypeptide or variant thereof, optionally with administration of an antigen. In some embodiments, the chemokine or variant is chemotactic for dendritic cells and/or macrophages, but not chemotactic for one or more of neutrophils, T-lymphocytes, monocytes, or eosinophils. In an embodiment, the chemokine or variant is a chemotaxin for immature but not mature dendritic cells.

公开(公告)号：EP1247103A2

公开(公告)日：2002-10-09

申请号：EP00988164.0

申请日：2000-12-18

申请人： Chemocentryx, Inc.

发明人： SCHALL, Thomas, J. ,  TALBOT, Dale ,  MIAO, Zhenhua ,  WEI, Zheng

IPC分类号： G01N33/68 ,  C12N15/10

CPC分类号： G01N33/6863 ,  C07K14/521 ,  C07K14/7158 ,  C07K2319/00 ,  G01N33/5088 ,  G01N33/531 ,  G01N2500/00

摘要： The invention provides methods, reagents and devices for analysis of receptor ligand interactions, determining the profile of receptor expression in cells and cell populations, and diagnostic and drug screening methods. The invention makes use of immobilized tethered ligand fusion proteins having a ligand domain, a stalk domain, and optionally an immobilization domain.

公开(公告)号：EP1274454B1

公开(公告)日：2005-12-28

申请号：EP01930632.3

申请日：2001-04-20

申请人： Chemocentryx, Inc.

发明人： SCHALL, Thomas, J. ,  TALBOT, Dale

IPC分类号： A61K39/39

CPC分类号： A61K39/39 ,  A61K38/00 ,  A61K2039/55522

摘要： The invention provides methods and compositions useful for inducing or enhancing an immune response in a human or non-human animal. In an embodiment, the method involves administering an antigen-presenting cell chemotaxin, such as a chemokine polypeptide or variant thereof, optionally with administration of an antigen. In some embodiments, the chemokine or variant is chemotactic for dendritic cells and/or macrophages, but not chemotactic for one or more of neutrophils, T-lymphocytes, monocytes, or eosinophils. In an embodiment, the chemokine or variant is a chemotaxin for immature but not mature dendritic cells.