公开(公告)号：EP3858832A1

公开(公告)日：2021-08-04

申请号：EP19878278.1

申请日：2019-10-29

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： LIU, Fei ,  FENG, Weiwei ,  WANG, Bin ,  XU, Hongjiang ,  WANG, Jinan ,  ZHANG, Xiquan ,  WANG, Shanchun ,  LIU, Yanlong ,  ZHANG, Jianqing ,  YAO, Yiyan ,  TANG, Xujing ,  SHI, Wei ,  ZHANG, Hongying ,  LI, Yang ,  TANG, Song ,  ZHU, Yizhong ,  LIU, Limin ,  GU, Hongmei ,  YANG, Ling

IPC分类号： C07D471/04 ,  C07D211/96 ,  C07D215/20 ,  A61K31/404 ,  A61P35/00

摘要： Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.