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公开(公告)号：EP3858832A1
公开(公告)日：2021-08-04
申请号：EP19878278.1
申请日：2019-10-29
发明人： LIU, Fei , FENG, Weiwei , WANG, Bin , XU, Hongjiang , WANG, Jinan , ZHANG, Xiquan , WANG, Shanchun , LIU, Yanlong , ZHANG, Jianqing , YAO, Yiyan , TANG, Xujing , SHI, Wei , ZHANG, Hongying , LI, Yang , TANG, Song , ZHU, Yizhong , LIU, Limin , GU, Hongmei , YANG, Ling
IPC分类号： C07D471/04 , C07D211/96 , C07D215/20 , A61K31/404 , A61P35/00
摘要： Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.
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公开(公告)号：EP3272746B1
公开(公告)日：2019-12-25
申请号：EP16767717.8
申请日：2016-03-18
申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： ZHANG, Xiquan , TANG, Song , FENG, Weiwei , TIAN, Xin , CHEN, Zhilin , GU, Hongmei , XU, Hongjiang , LIU, Fei
IPC分类号： C07D403/12 , C07D401/12 , C07D405/14 , A61K31/517 , A61K31/5377 , A61P35/00 , A61K31/4427 , A61K45/06 , C07D239/94 , C07D211/40
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公开(公告)号：EP4353722A1
公开(公告)日：2024-04-17
申请号：EP22815353.2
申请日：2022-06-02
发明人： WANG, Bin , LIU, Fei , FENG, Weiwei
IPC分类号： C07D471/04 , A61K31/496 , A61P35/00
CPC分类号： A61P35/00 , C07D471/04 , A61K31/496
摘要： A phosphate compound of a trifluoromethyl-substituted sulfonamide compound for selectively inhibiting anti-apoptotic protein BCL-2, a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof in the treatment of anti-apoptotic protein BCL-2-related diseases, such as cancer.
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公开(公告)号：EP4183421A1
公开(公告)日：2023-05-24
申请号：EP21855628.0
申请日：2021-08-13
申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. , Nanjing Shunxin Pharmaceuticals Co., Ltd. of Chiatai Tianqing Pharmaceutical Group
发明人： ZHANG, Xiquan , CHEN, Tianxi , FENG, Weiwei , ZHANG, Bing , TANG, Xiaoqi , XU, Tongjie , WANG, Xiaojin , SHENG, Huace , ZHANG, Zhengping , WANG, Hua , GAO, Yong
摘要： Provided is an antibody drug conjugate, specifically comprising a therapeutic antibody moiety, an intermediate linker moiety and a cytotoxic drug moiety which are linked. The therapeutic antibody moiety is an antibody against an HER2 target. The cytotoxic drug moiety is a camptothecin topoisomerase I inhibitor. The cytotoxic drug moiety or the linker-cytotoxic drug moiety is modified by means of deuterium substitution. The antibody drug conjugate can be used for the prevention or treatment of cancers.
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公开(公告)号：EP4389153A1
公开(公告)日：2024-06-26
申请号：EP22869373.5
申请日：2022-09-16
发明人： CHEN, Tianxi , XU, Tongjie , TANG, Xiaoqi , FENG, Weiwei , ZHANG, Zhengping
IPC分类号： A61K47/68 , C07K16/28 , C07D307/20 , A61P35/00
CPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , C07D307/20
摘要： Provided is an anti-HER3 antibody drug conjugate, specifically comprising an antibody moiety, an intermediate linker moiety, and a cytotoxic drug moiety which are linked together. The provided antibody drug conjugate achieves excellent anti-tumor activity or/and better safety. The provided antibody drug conjugate can be used for the treatment of cancer.
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公开(公告)号：EP4129998A1
公开(公告)日：2023-02-08
申请号：EP21796153.1
申请日：2021-04-29
发明人： FENG, Weiwei , LIU, Yanlong , ZHANG, Huihui , LIU, Fei , WANG, Bin , YAO, Yiyan , CHEN, Zhilin , ZHU, Jinlei , LU, Chenghui
IPC分类号： C07D471/04 , C07D211/96 , C07D215/20 , A61K31/404 , A61P35/00
摘要： A crystal of a trifluoromethyl/chloro disubstituted sulfonamide selective BCL-2 inhibitor, specifically related to a crystal of a compound of formula I, a preparation method therefor, and use thereof in preventing and treating diseases related to anti-apoptotic protein BCL-2, such as cancers.
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7.发明公开
公开(公告)号：EP3978494A1
公开(公告)日：2022-04-06
申请号：EP20813454.4
申请日：2020-05-22
发明人： LIU, Fei , LIU, Yanlong , XU, Hongjiang , ZHANG, Xiquan , WANG, Shanchun , ZHANG, Jianqing , FENG, Weiwei , WANG, Bin , WANG, Jinan , WANG, Yubing , TANG, Xujing , NIE, Quandeng
IPC分类号： C07D471/04 , C07D211/96 , C07D215/20 , A61K31/404 , A61P35/00
摘要： Disclosed is a methyl- and trifluoromethyl-containing disubstituted sulfonamide selective BCL-2 inhibitor; specifically disclosed are a compound of formula I, a stereoisomer or pharmaceutically acceptable salt of same, a preparation method therefor, and a pharmaceutical composition comprising the compound. Also disclosed are uses of the compound and of the pharmaceutical composition comprising the compound in treating anti-apoptotic protein BCL-2-related diseases such as cancer.
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