公开(公告)号：EP3851439A1

公开(公告)日：2021-07-21

申请号：EP19861061.0

申请日：2019-09-12

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： ZHANG, Yinsheng ,  XU, Hongjiang ,  REN, Jing ,  WANG, Qinglin ,  WU, Zheyang ,  JIN, Chao ,  SHI, Wei ,  WANG, Xiaojin ,  HE, Xiangyi ,  CHANG, Xiayun ,  WANG, Jie ,  ZHAO, Tianxiao

IPC分类号： C07D487/04 ,  A61K31/4985 ,  A61P19/02

摘要： The present application belongs to the field of pharmaceutical chemistry, and relates to a furo[3,4-b]pyrrole-containing BTK inhibitor, and in particular, to a compound of formula (I), a stereisomer or pharmacologically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in treating BTK-related diseases.

公开(公告)号：EP3915972A1

公开(公告)日：2021-12-01

申请号：EP19911146.9

申请日：2019-09-27

申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd

发明人： ZHANG, Yinsheng ,  AO, Wangwei ,  LI, Yuan ,  WANG, Hui ,  SHEN, Hangzhou ,  NI, Jie ,  ZHANG, Huan ,  WU, Jie ,  ZHANG, Li ,  CAO, Kai ,  LU, Peng ,  LIU, Xushi ,  WANG, Jie ,  ZHAO, Tianxiao ,  GE, Xingfeng ,  LU, Dandan ,  CHEN, Shuo ,  MA, Xueqin ,  SHI, Wei ,  WANG, Xiaojin ,  XU, Hongjiang

IPC分类号： C07D207/34 ,  A61K31/40 ,  A61P31/20

摘要： Provided is a compound of formula I or II, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and the medical uses thereof in treating diseases benefiting from the capsid protein assembly inhibitor, particularly diseases caused by hepatitis B virus infection.

公开(公告)号：EP3778569A1

公开(公告)日：2021-02-17

申请号：EP19777163.7

申请日：2019-03-29

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： ZHANG, Yinsheng ,  AO, Wangwei ,  LI, Yuan ,  WANG, Hui ,  SHEN, Hangzhou ,  NI, Jie ,  ZHANG, Huan ,  WU, Jie ,  ZHANG, Li ,  CAO, Kai ,  LU, Peng ,  LIU, Xushi ,  WANG, Jie ,  ZHAO, Tianxiao ,  GE, Xingfeng ,  LU, Dandan ,  CHEN, Shuo ,  MA, Xueqin ,  SHI, Wei ,  WANG, Xiaojin ,  XU, Hongjiang

IPC分类号： C07D207/34 ,  C07D405/12 ,  A61K31/4025 ,  A61P31/20

摘要： A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.