公开(公告)号：EP3498704A1

公开(公告)日：2019-06-19

申请号：EP17838796.5

申请日：2017-08-11

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd. ,  Lianyungang Runzhong Pharmaceutical Co., Ltd. ,  Centaurus BioPharma Co., Ltd.

发明人： SANG, Guangming ,  LIU, Lin ,  ZHANG, Aiming ,  QIAO, Jiabin ,  GUO, Xiaopeng ,  ZHANG, Xiquan ,  XIA, Chunguang

IPC分类号： C07D405/04 ,  A61K31/4035 ,  A61P5/50 ,  A61P3/00 ,  A61P35/00 ,  A61P25/00 ,  A61P3/12

摘要： The present application relates a crystal of a compound represented by Formula (I), a salt thereof, and a crystal of the salt thereof, a method for preparing the crystal of the compound represented by Formula (I), the salt thereof, and the crystal of the salt thereof, a crystal comprising the compound represented by Formula (I), a crystal composition comprising the crystal of the salt thereof, a pharmaceutical composition thereof, and medical uses thereof.

公开(公告)号：EP3828192A1

公开(公告)日：2021-06-02

申请号：EP19841191.0

申请日：2019-07-24

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： LIU, Lin ,  ZHAO, Rui ,  SANG, Guangming ,  ZHOU, Xingjian ,  GUO, Xiaopeng ,  ZHANG, Aiming ,  WU, Gang ,  XIA, Chunguang ,  ZHANG, Xiquan

IPC分类号： C07H19/073 ,  C07H1/00

摘要： The present application relates to a method for preparing trifluridine, comprising reacting a compound of formula III with a compound of formula IV in a first solvent in the presence of an acid to obtain a compound of formula II, and performing further reaction to obtain trifluridine.

公开(公告)号：EP3705487A1

公开(公告)日：2020-09-09

申请号：EP18873405.7

申请日：2018-11-01

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： ZHANG, Xiquan ,  CHENG, Xingdong ,  ZHANG, Aiming ,  XIA, Chunguang ,  CHEN, Lang ,  GAO, Ce

IPC分类号： C07J9/00

摘要： The present application belongs to the field of pharmaceutical chemistry, and relates to a method for preparing a cholic acid compound. Specifically, the present application provides a process for preparing a compound as shown in formula I, comprising subjecting a compound of formula 2 to an oxidization reaction to obtain a compound of formula 3; attaching a trimethylsilyl group to the compound of formula 3 to obtain a compound of formula 4; reacting the compound of formula 4 with acetaldehyde to obtain a compound of formula 5; subjecting the compound of formula 5 to a catalytic hydrogenation reaction to obtain a compound of formula 6; and converting a cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I. The preparation method has high yield, requires less purification operations, and is suitable for industrial application.