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公开(公告)号：EP4355755A1
公开(公告)日：2024-04-24
申请号：EP22825588.1
申请日：2022-06-13
发明人： BURNS, Christopher J. , COBURN, Glen , CHU, Guo-Hua , CONDON, Stephen M. , BOYD, Steven A. , PEVEAR, Daniel C.
IPC分类号： C07H13/12 , A61P31/14 , C07H13/04 , C07H13/06 , C07H15/04 , C07H15/06 , C07H19/073 , C07H19/167 , C07H19/173 , C07H19/20 , C07H7/06 , A61K31/706
CPC分类号： A61K31/706 , A61P31/14 , C07H1/00 , C07H15/26
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公开(公告)号：EP3790931B1
公开(公告)日：2023-09-27
申请号：EP19725532.6
申请日：2019-05-07
IPC分类号： C09B11/24 , C09B57/00 , C07H19/073 , C07H21/00 , G01N33/483
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公开(公告)号：EP4047098A1
公开(公告)日：2022-08-24
申请号：EP19942121.5
申请日：2019-08-20
发明人： CHEN, Xi , LIAO, Sha , ZHANG, Wenwei , CHEN, Ao , ZHAO, Jie
IPC分类号： C12Q1/68 , C07H19/073
摘要： Provided are a method for sequencing polynucleotides based on optical signal kinetics of luminescent labels and secondary luminescent signals, in which different luminescence forms and luminescence timings are applied to distinguish the sequential incorporation of different nucleotides, so as to realize the sequencing of the polynucleotides.
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公开(公告)号：EP3885351A3
公开(公告)日：2021-12-22
申请号：EP21170140.4
申请日：2017-11-09
发明人： WADA, Takeshi , SAITO, Tatsuya , ISHII, Yuka , NUKAGA, Yohei
IPC分类号： C07H19/073 , C07H19/173 , C07H21/04 , C07H23/00 , C07H1/00 , C07F5/02 , C07F9/6584 , C07F9/6558
摘要： A polymerizable compound represented by the following Formula E-1 or Formula E-4:
The polymerizable compound according to the present disclosure is allows stereoselective synthesis of a boranophosphate oligomer, regardless of whether a base in a nucleoside has an amino group. The boranophosphate oligomer is used as an antisense molecule and has the advantages of having high nuclease resistance, high RNA interference (RNAi) activity, higher affinity for RNA than DNA, a low nonspecific interaction with proteins, and applicability to boron neutron capture therapy (BNCT).-
公开(公告)号：EP3514164B1
公开(公告)日：2020-09-09
申请号：EP17850964.2
申请日：2017-09-14
发明人： MINAGAWA Hirotaka , HORII Katsunori , AKITOMI Jou , KANEKO Naoto , WAGA Iwao , KUWAHARA Masayasu
IPC分类号： C07H19/073 , C07H19/10 , C07H21/00 , C12N9/10 , C12N15/115
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公开(公告)号：EP3684780A1
公开(公告)日：2020-07-29
申请号：EP18778972.2
申请日：2018-09-18
申请人： Nucana PLC
IPC分类号： C07H1/00 , C07H19/073
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公开(公告)号：EP3204121B1
公开(公告)日：2019-06-19
申请号：EP15849800.6
申请日：2015-10-08
IPC分类号： C07H19/12 , C07H19/067 , C07H19/073 , C07F7/18 , A61K31/706 , A61K31/695 , A61P35/00 , A61P35/02
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公开(公告)号：EP3140286B1
公开(公告)日：2018-12-26
申请号：EP15789510.3
申请日：2015-05-11
发明人： REDDINGTON, Mark , COOK, Ronald, M. , AYER, Ben
IPC分类号： C07D455/04 , C07H19/04 , C07H19/073 , C12Q1/68
CPC分类号： C07D471/06 , C07D455/04 , C07F9/6561 , C07H17/02 , C07H21/00 , C12Q1/6818
摘要： The present invention provides quenchers of excited state energy, probes and other conjugates comprising these quenchers, and methods of their use.
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公开(公告)号：EP3172216B1
公开(公告)日：2018-10-10
申请号：EP14772458.7
申请日：2014-08-22
IPC分类号： C07F9/24 , C07H19/073 , A61K33/42 , A61P35/00
CPC分类号： C07H19/10 , A61K33/42 , C07F9/24 , C07F9/6561 , C07H19/073
摘要： The subject matter of the invention is novel 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
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公开(公告)号：EP3315501A1
公开(公告)日：2018-05-02
申请号：EP16773558.8
申请日：2016-04-06
IPC分类号： C07D491/147 , C07D239/10 , C07H19/073 , A61K31/519 , A61K31/513 , A61P31/14 , A61P31/12
摘要： The invention relates to the field of organic chemistry and medicine, and more particularly to synthetic substances of the pyrimidine series, namely 2-chloro-5-phenyl-5 H- pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivatives, having antiviral activity. Claimed are a drug with antiviral activity against HIV infection and hepatitis B virus, containing 2-chloro-5-phenyl-5H-pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivatives of the general formula shown, where: X is selected from the group: H, NO 2 , Hal, OMe; R1 is selected from the group: Cl, OH; and R2 is selected from the group: Cl, SH, OH; and a drug with antiviral activity against HIV infection, containing a 2-chloro-5-phenyl-5H-pyrimido[5',4':5,6]pyrano[2,3-d]pyrimidine-4-ol derivative of the general formula shown, where: X is selected from the group: H, NO 2 , Hal, OMe; R1 is selected from the group: Cl, OH; and R2 is selected from the group: Cl, SH, OH in combination with a reverse transcriptase inhibitor selected from Retrovir, or in combination with a protease inhibitor selected from Lopinavir, in an effective amount. The result is an effective drug with antiviral activity.
摘要翻译： 本发明涉及有机化学和医药领域，更具体地涉及嘧啶系列的合成物质，即2-氯-5-苯基-5H-嘧啶并[5'，4'：5,6]吡喃并[2,1- 3-d]嘧啶-4-醇衍生物，具有抗病毒活性。 声称含有2-氯-5-苯基-5H-嘧啶并[5'，4'：5,6]吡喃并[2,3-d]嘧啶-4-酮的抗HIV感染和乙型肝炎病毒的抗病毒活性的药物， 其中：X选自：H，NO 2，Hal，OMe; R1选自：Cl，OH; 并且R2选自：Cl，SH，OH; 和一种具有抗HIV感染的抗病毒活性的药物，该药物含有2-氯-5-苯基-5H-嘧啶并[5'，4'：5,6]吡喃并[2,3-d]嘧啶-4-醇衍生物 所示通式表示，其中：X选自：H，NO 2，Hal，OMe; R1选自：Cl，OH; R2选自：Cl，SH，OH与选自Retrovir的逆转录酶抑制剂或与选自洛匹那韦的蛋白酶抑制剂组合的有效量的组合。 其结果是具有抗病毒活性的有效药物。
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