公开(公告)号：EP3919485A1

公开(公告)日：2021-12-08

申请号：EP20749295.0

申请日：2020-01-31

申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd

发明人： ZHANG, Xiquan ,  WANG, Shanchun ,  GENG, Wenjun ,  LIU, Yanlong ,  ZHANG, Huihui ,  LIU, Fei ,  ZHU, Shanliang ,  LI, Xinlu ,  ZHAO, Rui ,  GU, Hongmei

IPC分类号： C07D401/12 ,  A61P35/00 ,  A61K31/4709

摘要： The present application relates to the field of medicine, and relates to crystals of quinoline derivatives, and in particular, to crystals of a quinoline derivative anhydride and a solvate, as well as a method for preparing the crystals, pharmaceutical compositions containing the crystals, and a use thereof in the field of medicine. The present application further provides a preparation method therefor, which has a high yield, has mild crystallization conditions, is suitable for industrial production, and may better meet the needs of the pharmaceutical industry.

公开(公告)号：EP3896063A1

公开(公告)日：2021-10-20

申请号：EP19897084.0

申请日：2019-12-13

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： QIAN, Wenyuan ,  WANG, Hongjian ,  ZHANG, Ming ,  LIU, Fei ,  XING, Lei ,  HU, Zhongyuan ,  GUO, Yahui ,  LIU, Yanlong ,  ZHANG, Huihui

IPC分类号： C07D401/14 ,  A61K31/498 ,  A61K31/4709 ,  A61P35/00 ,  A61P29/00

摘要： Provided is a salt of an Syk inhibitor and a crystalline form thereof, and more specifically, provided are 5-fluoro-1-methyl-3-((5-(4-(oxetan-3-yl)piperazine-1)-yl)pyridin-2-yl)amino)-6-(1H-pyrazol-3-yl)quinoline-2(1H )-ketamine hydrochloride, a crystalline form thereof, a preparation method therefor, a pharmaceutical composition thereof and a use thereof. The hydrochloride of the compound represented by formula I and the crystalline form thereof have good salt-forming properties, high stability and low hygroscopicity, have advantages in terms of physical properties, safety and metabolic stability, and have value in prepared medicines.

公开(公告)号：EP4129998A1

公开(公告)日：2023-02-08

申请号：EP21796153.1

申请日：2021-04-29

申请人： Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

发明人： FENG, Weiwei ,  LIU, Yanlong ,  ZHANG, Huihui ,  LIU, Fei ,  WANG, Bin ,  YAO, Yiyan ,  CHEN, Zhilin ,  ZHU, Jinlei ,  LU, Chenghui

IPC分类号： C07D471/04 ,  C07D211/96 ,  C07D215/20 ,  A61K31/404 ,  A61P35/00

摘要： A crystal of a trifluoromethyl/chloro disubstituted sulfonamide selective BCL-2 inhibitor, specifically related to a crystal of a compound of formula I, a preparation method therefor, and use thereof in preventing and treating diseases related to anti-apoptotic protein BCL-2, such as cancers.