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公开(公告)号：EP3489233A1
公开(公告)日：2019-05-29
申请号：EP17830503.3
申请日：2017-07-21
发明人： YAO, Yuanshan , CHEN, Bin , CHEN, Yuan , LI, Ao , XU, Ran , HUANG, Zhensheng , TIAN, Dongdong , LI, Hongwei , YANG, Chengshuai , LI, Jian , CHEN, Shuhui
IPC分类号： C07D409/04 , C07D409/14 , C07D409/06 , C07D495/04 , A61K31/4439 , A61K31/405 , A61K31/4365 , A61P43/00
摘要： The present application discloses an indole as represented by formula (I) used as a CRTH2 inhibitor, and a pharmaceutically acceptable salt or tautomer of the indole, and an application of same in treating a disease related to a CRTH2 receptor.
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公开(公告)号：EP3489235A1
公开(公告)日：2019-05-29
申请号：EP17830501.7
申请日：2017-07-21
发明人： CHEN, Bin , YAO, Yuanshan , CHEN, Yuan , LI, Ao , XU, Ran , HUANG, Zhensheng , TIAN, Dongdong , LI, Hongwei , YANG, Chengshuai , LI, Jian , CHEN, Shuhui
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4985 , A61K31/437 , A61K31/4709 , A61K31/444 , A61P43/00
摘要： Provided are a tricyclic compound as shown in formula (I) as a CRTH2 inhibitor, or a pharmaceutically acceptable salt, a tautomer, a stereoisomer or a solvate thereof, and the use thereof in treating diseases related to CRTH2 receptors.
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公开(公告)号：EP3741754A1
公开(公告)日：2020-11-25
申请号：EP19741497.2
申请日：2019-01-18
发明人： YAO, Yuanshan , CHEN, Bin , GAO, Feng , CHEN, Yuan , XU, Ran , YANG, Chengshuai , ZHANG, Sheng , LI, Jian , CHEN, Shuhui
IPC分类号： C07D409/06 , C07D495/00 , A61K31/382 , A61K31/405 , A61P37/08 , A61P11/02
摘要： Disclosed are a crystal form of an indole derivative (compound 1) and a pharmaceutical composition and preparation method thereof. The crystal form is used to prepare a drug for treating a disease related to a CRTH2 receptor.
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公开(公告)号：EP3138843B1
公开(公告)日：2019-11-27
申请号：EP15786613.8
申请日：2015-04-21
发明人： WU, Lingyun , YAO, Yuanshan , CHEN, Zhaoguo , CHEN, Shuhui
IPC分类号： C07D487/04 , C07D471/04 , C07D401/12 , A61K31/4725 , A61K31/55 , A61P9/10 , A61P27/06 , A61P9/12
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公开(公告)号：EP3138843A1
公开(公告)日：2017-03-08
申请号：EP15786613.8
申请日：2015-04-21
发明人： WU, Lingyun , YAO, Yuanshan , CHEN, Zhaoguo , CHEN, Shuhui
IPC分类号： C07D487/04 , C07D471/04 , C07D401/12 , A61K31/4725 , A61K31/55 , A61P9/10 , A61P27/06 , A61P9/12
摘要： The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to pharmaceutically acceptable uses thereof. Specifically, the present invention relates to a compound as represented by formula (I), or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明公开了一类作为RHO激酶抑制剂的异喹啉磺酰基衍生物及其药物组合物，并涉及其药学上可接受的用途。 具体而言，本发明涉及如式（I）所示的化合物或其药学上可接受的盐。
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