公开(公告)号：EP3483288A2

公开(公告)日：2019-05-15

申请号：EP18196397.6

申请日：2012-11-29

申请人： Children's Hospital Medical Center

发明人： SADHASIVAM, Senthilkumar ,  CHIDAMBARAN, Vidya ,  MCAULIFFE, John ,  ZHANG, Kejian ,  MELLER, Jaroslaw ,  PROWS, Cynthia A. ,  FUKUDA, Tsuyoshi

IPC分类号： C12Q1/6883 ,  C12N15/11 ,  C12N15/12 ,  C07K7/06

摘要： Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and inadequate pain relief. Embodiments of the invention relate to the association between genes, specific polymorphisms of genes, and non-genetic factors with inadequate pain relief and anesthesia-, analgesic, and/or opioid-related adverse effects. Embodiments of the invention can be used to determine and manage patient risk factors for development of adverse perioperative effects and can allow for personalized anesthesia and pain management for improvement of pain control and reduction of anesthesia-, analgesic-, and opioid-related adverse outcomes. These methods and compositions apply to non-surgical pain management with opioids. Therefore, patients who are genetically predisposed to risk of inadequate pain relief and/or serious side effects from anesthesia, analgesics, and/or opioids can be identified and individualized treatment plans developed for implementation by the clinician to improve clinical and economic outcomes.

公开(公告)号：EP2785874A1

公开(公告)日：2014-10-08

申请号：EP12854522.5

申请日：2012-11-29

申请人： Children's Hospital Medical Center

发明人： SADHASIVAM, Senthilkumar ,  CHILDAMBARAN, Vidya ,  MCAULIFFE, John ,  ZHANG, Kejian ,  MELLER, Jarolsaw ,  PROWS, Cynthia A. ,  FUKUDA, Tsuyoshi

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N15/12 ,  C07K7/06

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

摘要： Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and inadequate pain relief. Embodiments of the invention relate to the association between genes, specific polymorphisms of genes, and non-genetic factors with inadequate pain relief and anesthesia-, analgesic, and/or opioid-related adverse effects. Embodiments of the invention can be used to determine and manage patient risk factors for development of adverse perioperative effects and can allow for personalized anesthesia and pain management for improvement of pain control and reduction of anesthesia-, analgesic-, and opioid-related adverse outcomes. These methods and compositions apply to non-surgical pain management with opioids. Therefore, patients who are genetically predisposed to risk of inadequate pain relief and/or serious side effects from anesthesia, analgesics, and/or opioids can be identified and individualized treatment plans developed for implementation by the clinician to improve clinical and economic outcomes.

公开(公告)号：EP2714919A1

公开(公告)日：2014-04-09

申请号：EP12789354.3

申请日：2012-05-25

申请人： University Of Cincinnati ,  Cincinnati Children's Hospital Medical Center

发明人： CLARK, Joseph,F. ,  PYNE-GEITHMAN, Gail ,  KUROSAWA, Yuko ,  ZHANG, Kejian ,  ZHANG, Wenying ,  KEDDACHE, Mehdi

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/156 ,  C12Q2531/113 ,  C12Q2537/143

摘要： Amplification primers, sequencing primers, kits for screening, and screening methods for identifying a
SLC6A8 creatine transporter gene mutation are disclosed. The screening method includes treating a sample of DNA with polymerase chain reaction amplification primers for amplifying regions of the DNA having
SLC6A8 to produce a first, second, and third amplification product, sequencing the first, second, and third amplification products with sequencing primer pairs to provide a DNA sequence of
SLC6A8 in the sample, and comparing the DNA sequence of
SLC6A8 with a reference DNA sequence of
SLC6A8 .

公开(公告)号：EP3483288A3

公开(公告)日：2019-06-05

申请号：EP18196397.6

申请日：2012-11-29

申请人： Children's Hospital Medical Center

发明人： SADHASIVAM, Senthilkumar ,  CHIDAMBARAN, Vidya ,  MCAULIFFE, John ,  ZHANG, Kejian ,  MELLER, Jaroslaw ,  PROWS, Cynthia A. ,  FUKUDA, Tsuyoshi

IPC分类号： C12Q1/6883 ,  C12N15/11 ,  C12N15/12 ,  C07K7/06

摘要： Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and inadequate pain relief. Embodiments of the invention relate to the association between genes, specific polymorphisms of genes, and non-genetic factors with inadequate pain relief and anesthesia-, analgesic, and/or opioid-related adverse effects. Embodiments of the invention can be used to determine and manage patient risk factors for development of adverse perioperative effects and can allow for personalized anesthesia and pain management for improvement of pain control and reduction of anesthesia-, analgesic-, and opioid-related adverse outcomes. These methods and compositions apply to non-surgical pain management with opioids. Therefore, patients who are genetically predisposed to risk of inadequate pain relief and/or serious side effects from anesthesia, analgesics, and/or opioids can be identified and individualized treatment plans developed for implementation by the clinician to improve clinical and economic outcomes.

公开(公告)号：EP2785874B1

公开(公告)日：2018-09-26

申请号：EP12854522.5

申请日：2012-11-29

申请人： Children's Hospital Medical Center

发明人： SADHASIVAM, Senthilkumar ,  CHIDAMBARAN, Vidya ,  MCAULIFFE, John ,  ZHANG, Kejian ,  MELLER, Jarolsaw ,  PROWS, Cynthia A. ,  FUKUDA, Tsuyoshi

IPC分类号： C12Q1/68 ,  C12N15/11 ,  C12N15/12 ,  C07K7/06

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/172

摘要： Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to anesthesia, analgesics, opioids, and inadequate pain relief. Embodiments of the invention relate to the association between genes, specific polymorphisms of genes, and non-genetic factors with inadequate pain relief and anesthesia-, analgesic, and/or opioid-related adverse effects. Embodiments of the invention can be used to determine and manage patient risk factors for development of adverse perioperative effects and can allow for personalized anesthesia and pain management for improvement of pain control and reduction of anesthesia-, analgesic-, and opioid-related adverse outcomes. These methods and compositions apply to non-surgical pain management with opioids. Therefore, patients who are genetically predisposed to risk of inadequate pain relief and/or serious side effects from anesthesia, analgesics, and/or opioids can be identified and individualized treatment plans developed for implementation by the clinician to improve clinical and economic outcomes.

公开(公告)号：EP3233115A2

公开(公告)日：2017-10-25

申请号：EP15871126.7

申请日：2015-12-17

申请人： Children's Hospital Medical Center

发明人： JODELE, Sonata ,  ZHANG, Kejian ,  DAVIES, Stella

IPC分类号： A61K39/00

CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Embodiments described herein relate to evaluating risk of transplant-associated thrombotic microangiopathy. Disclosed herein are methods for determining the risk of developing transplant-associated thrombotic microangiopathy, as well as the likely severity of the outcome. Some embodiments include selecting and administering a treatment for transplant-associated thrombotic microangiopathy in subjects identified as having elevated risk.

摘要翻译： 本文描述的实施方案涉及评估移植物相关的血栓性微血管病的风险。 本文公开了用于确定发生移植物相关血栓性微血管病的风险以及结果的可能严重程度的方法。 一些实施方案包括在被鉴定为具有升高的风险的受试者中选择和施用治疗移植物相关的血栓性微血管病。