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公开(公告)号：EP3851435A1
公开(公告)日：2021-07-21
申请号：EP19867637.1
申请日：2019-06-05
发明人： HE, Kunlun , GAO, Xiaojian , LIU, Chunlei , ZHANG, Zeyu , LI, Xin , LI, Chen , LUO, Yunfu , LEI, Maoyi , LI, Junmiao , WANG, Yiwei
IPC分类号： C07D405/14 , C07D471/04 , C07D417/14 , A61K31/506 , C07D491/107 , A61P39/00 , A61P11/00 , A61P9/00 , A61P9/12
摘要： The present disclosure provides application of a compound in conformity with a general formula I and an isomer or pharmaceutically acceptable salt thereof to preparation of a medicinal composition for treating or preventing a high altitude disease. The high altitude disease is selected from an acute high altitude disease and a chronic high altitude disease generated in a high altitude environment with an altitude of 2,000m or above.
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公开(公告)号：EP3851106A1
公开(公告)日：2021-07-21
申请号：EP19867766.8
申请日：2019-06-05
发明人： HE, Kunlun , ZHANG, Zeyu , GAO, Xiaojian , LIU, Chunlei , LI, Xin , LI, Chen , QIAN, Wenyuan , YANG, Chundao , XU, Guanghai , WANG, Yiwei
IPC分类号： A61K31/497 , C07D401/14 , A61P43/00
摘要： The present disclosure provides application of a compound in conformity with a general formula I, and an isomer or pharmaceutically acceptable salt thereof to preparation of a medicinal composition for treating and/or preventing a high altitude disease. The high altitude disease is selected from an acute high altitude disease or a chronic high altitude disease generated in a high altitude environment with an altitude of 2,000m or above.
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3.发明公开(2E)-3-PHENYL-N-[2,2,2-TRIFLUORO-1-[[(8-QUINOLINEAMINO)THIOMETHYL]AMINO]ETHYL]-2-ACRYLAMIDE AND PHARMACEUTICAL USES THEREOF 有权（2E）-3-苯基-N- [2,2,2-三氟-1 - [[（8-喹啉氨基）甲基]氨基]乙酰基] -2-丙烯酰胺在SEINE PHARMAZEUCHECHE VERWENDUNG
公开(公告)号：EP2589593A1
公开(公告)日：2013-05-08
申请号：EP10851189.0
申请日：2010-05-14
发明人： HE, Kunlun , LI, Song , WANG, Lili , LI, Xin , ZHONG, Wu , HU, Guoliang , WANG, Jie , LI, Ruijun , LIU, Chunlei , XIAO, Junhai , LONG, Long , LI, Wei , CHEN, Hua
IPC分类号： C07D215/38 , A61K31/47 , A61P9/00
CPC分类号： C07D215/40 , A61K31/47
摘要： The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis
摘要翻译： 本发明涉及式I的丙烯酰胺化合物或其异构体，药学上可接受的盐和溶剂合物，其涉及包含所述化合物或其异构体，药学上可接受的盐和溶剂合物，以及药学上可接受的载体，赋形剂或稀释剂， 以及该化合物或组合物用于预防和/或治疗与心肌细胞凋亡相关的疾病或病症的用途
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4.发明公开ACRYLAMIDE COMPOUNDS AND USE THEREOF FOR INHIBITING APOPTOSIS 有权国际艾睿威睿IN EN OSE OSE OSE OSE OSE OSE OSE OSE OSE OSE OSE OSE OSE OSE OSE
公开(公告)号：EP2573078A1
公开(公告)日：2013-03-27
申请号：EP10851188.2
申请日：2010-05-14
发明人： HE, Kunlun , LI, Song , ZHONG, Wu , LIU, Juan , WANG, Lili , LI, Xin , HU, Guoliang , WANG, Jie , LONG, Long , XIAO, Junhai , ZHENG, Zhibing , LI, Wei , LI, Ruijun , LIU, Chunlei , TANG, Jie
IPC分类号： C07D333/04 , C07D333/10 , C07D409/12 , C07D295/21 , C07C335/12 , A61K31/381 , A61K31/4709 , A61K31/496 , A61K31/435 , A61K31/5377 , A61K31/17 , A61P9/00 , A61P43/00
CPC分类号： A61K31/18 , A61K31/17 , A61K31/381 , A61K31/435 , A61K31/4453 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C335/12 , C07D295/194 , C07D295/21 , C07D333/24 , C07D409/12
摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof; the present invention also relates to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. The present invention also relates to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for combating apoptosis, preventing or treating a disease or disorder associated with apoptosis; especially use for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译： 本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物; 本发明还涉及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物以及药学上可接受的载体，赋形剂或稀释剂的组合物。 本发明还涉及式I化合物或异构体，其药学上可接受的盐和溶剂合物用于防治凋亡，预防或治疗与细胞凋亡相关的疾病或病症的用途; 特别用于保护心肌细胞，预防或治疗与心肌细胞凋亡相关的疾病或病症。
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公开(公告)号：EP2570403A1
公开(公告)日：2013-03-20
申请号：EP10851187.4
申请日：2010-05-14
发明人： HE, Kunlun , LI, Song , ZHONG, Wu , LIU, Juan , WANG, Lili , LI, Xin , HU, Guoliang , LONG, Long , XIAO, Junhai , ZHENG, Zhibing , LI, Wei , LI, Ruijun , LIU, Chunlei , BAI, Jie
IPC分类号： C07C275/24 , C07C275/26 , C07C275/28 , C07D215/40 , C07D333/04 , C07D333/10 , C07D275/02 , C07D277/02 , A61K31/17 , A61K31/4706 , A61K31/381 , A61K31/425 , A61P9/00 , A61P43/00
CPC分类号： C07C275/28 , C07D215/40
摘要： The present invention relates to a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof. The present invention also relates to a composition comprising a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluents. Further, the present invention relates to use of a compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof for anti-apoptosis, preventing or treating a disease or disorder associated with apoptosis; especially useful for protecting cardiomyocyte, preventing or treating a disease or disorder associated with cardiomyocyte apoptosis.
摘要翻译： 本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂化物。 本发明还涉及包含式I化合物或其异构体，药学上可接受的盐和溶剂化物以及药学上可接受的载体，赋形剂或稀释剂的组合物。 此外，本发明涉及式I化合物或其异构体，药学上可接受的盐和溶剂合物用于抗凋亡，预防或治疗与细胞凋亡相关的疾病或病症的用途; 特别用于保护心肌细胞，预防或治疗与心肌细胞凋亡相关的疾病或病症。
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公开(公告)号：EP2573078B1
公开(公告)日：2016-11-02
申请号：EP10851188.2
申请日：2010-05-14
发明人： HE, Kunlun , LI, Song , ZHONG, Wu , LIU, Juan , WANG, Lili , LI, Xin , HU, Guoliang , WANG, Jie , LONG, Long , XIAO, Junhai , ZHENG, Zhibing , LI, Wei , LI, Ruijun , LIU, Chunlei , TANG, Jie
IPC分类号： C07D333/04 , C07D333/10 , C07D409/12 , C07D295/21 , C07C335/12 , A61K31/381 , A61K31/4709 , A61K31/496 , A61K31/435 , A61K31/5377 , A61K31/17 , A61P9/00 , A61P43/00
CPC分类号： A61K31/18 , A61K31/17 , A61K31/381 , A61K31/435 , A61K31/4453 , A61K31/4709 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C335/12 , C07D295/194 , C07D295/21 , C07D333/24 , C07D409/12
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7.发明授权(2E)-3-PHENYL-N-[2,2,2-TRIFLUORO-1-[[(8-QUINOLINEAMINO)THIOMETHYL]AMINO]ETHYL]-2-ACRYLAMIDE AND PHARMACEUTICAL USES THEREOF 有权（2E）-3-苯基-N- [2,2,2-三氟-1 - [[（8- CHINOLINAMINO）硫代甲基]氨基]乙基] -2-丙烯酰胺及其药物用途
公开(公告)号：EP2589593B1
公开(公告)日：2015-04-01
申请号：EP10851189.0
申请日：2010-05-14
发明人： HE, Kunlun , LI, Song , WANG, Lili , LI, Xin , ZHONG, Wu , HU, Guoliang , WANG, Jie , LI, Ruijun , LIU, Chunlei , XIAO, Junhai , LONG, Long , LI, Wei , CHEN, Hua
IPC分类号： C07D215/38 , C07D215/40 , A61K31/47 , A61P9/00
CPC分类号： C07D215/40 , A61K31/47
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公开(公告)号：EP2570403B1
公开(公告)日：2015-03-11
申请号：EP10851187.4
申请日：2010-05-14
发明人： HE, Kunlun , LI, Song , ZHONG, Wu , LIU, Juan , WANG, Lili , LI, Xin , HU, Guoliang , LONG, Long , XIAO, Junhai , ZHENG, Zhibing , LI, Wei , LI, Ruijun , LIU, Chunlei , BAI, Jie
IPC分类号： C07C275/24 , C07C275/26 , C07C275/28 , C07D215/40 , C07D333/04 , C07D333/10 , C07D275/02 , C07D277/02 , A61K31/17 , A61K31/4706 , A61K31/381 , A61K31/425 , A61P9/00 , A61P43/00
CPC分类号： C07C275/28 , C07D215/40
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