公开(公告)号：EP3359522A1

公开(公告)日：2018-08-15

申请号：EP16853064.0

申请日：2016-09-09

申请人： Chiral Quest (suzhou) Co., Ltd. ,  Jiangxi Long Life Bio-pharmaceutical Co., Ltd.

发明人： WU, Shengwen ,  LI, Wenge ,  WU, Lei ,  ZOU, Li ,  HU, Siming ,  XU, Tengyue ,  LIU, Hongfeng ,  TAO, Yi ,  CHI, Yongxiang

IPC分类号： C07C271/16 ,  C07C269/06 ,  C07C271/18 ,  C07C269/00

CPC分类号： C07C269/06 ,  C07C231/12 ,  C07C269/00 ,  C07C271/64 ,  C07C233/47 ,  C07C271/22 ,  C07C233/18

摘要： A process is provided for preparation of (R)-N-Boc biphenyl alaninol.It provides a preparation process for a compound outlined as compound 4, which includes these operations: in one of the alcohol solvents, asymmetric hydrogenation of 5 in the presence of [Rh(Duanphos)(X)]Y and hydrogen to provide compound 4. Here "Duanphos" is (Rc,Sp)-Duanphos or (Sc,Rp)-Duanphos; X is NBD or/and COD; Y is one or more of BF4, PF6, SbF6. This process has a lot of advantages, such as low cost, safe operation, less pollution and high yield. The product was obtained in >99% purity and ee which is suitable to scale up in industrial scale.

公开(公告)号：EP3359522B1

公开(公告)日：2020-02-26

申请号：EP16853064.0

申请日：2016-09-09

申请人： Chiral Quest (suzhou) Co., Ltd. ,  Jiangxi Long Life Bio-pharmaceutical Co., Ltd.

发明人： WU, Shengwen ,  LI, Wenge ,  WU, Lei ,  ZOU, Li ,  HU, Siming ,  XU, Tengyue ,  LIU, Hongfeng ,  TAO, Yi ,  CHI, Yongxiang

IPC分类号： C07C271/16 ,  C07C269/06 ,  C07C271/18 ,  C07C269/00 ,  C07C231/12 ,  C07C233/47 ,  C07C271/22 ,  C07C233/18 ,  C07C271/64