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公开(公告)号：EP3297992B1
公开(公告)日：2020-02-05
申请号：EP16800269.9
申请日：2016-05-20
发明人： LEE, Changsik , LEE, Jaekwang , SONG, Hyeseung , BAE, Daekwon , HA, Nina , KIM, Il Hyang
IPC分类号： C07D241/04 , C07D211/34 , A61K31/4965 , A61K31/435 , A61P9/00 , A61P35/00 , A61P37/00
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2.发明公开HETEROCYCLICALKYL DERIVATIVE COMPOUNDS AS SELECTIVE HISTONE DEACETYLASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开杂环化合物衍生物化合物作为选择性活性的脱乙酰酶抑制剂和包含该化合物的药物组合物
公开(公告)号：EP3297992A1
公开(公告)日：2018-03-28
申请号：EP16800269.9
申请日：2016-05-20
发明人： LEE, Changsik , LEE, Jaekwang , SONG, Hyeseung , BAE, Daekwon , HA, Nina , KIM, Il Hyang
IPC分类号： C07D241/04 , C07D211/34 , A61K31/4965 , A61K31/435
摘要： The present invention relates to novel heterocyclicalkyl derivatives having histone deacetylase (HDAC) inhibitory activity, optical isomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel heterocyclicalkyl derivatives. The novel heterocyclicalkyl derivatives according to the present invention are selective histone deacetylase (HDAC) inhibitors, and may be effectively used for the treatment of histone deacetylase-mediated diseases, such as cell proliferative diseases, inflammatory diseases, autosomal dominant diseases, genetic metabolic diseases, autoimmune diseases, acute/chronic neurological disease, hypertrophy, heart failure, ocular diseases, or neurodegenerative diseases.
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