公开(公告)号：EP1590315A1

公开(公告)日：2005-11-02

申请号：EP03789268.4

申请日：2003-12-13

申请人： Clariant GmbH

发明人： NICKEL, Uwe ,  WEHLE, Detlef ,  UNVERDORBEN, Leonhard ,  FORSTINGER, Klaus ,  KIM, Hieng

IPC分类号： C07C67/46 ,  C07D235/26 ,  C07C303/22 ,  C07C231/04

CPC分类号： C07D235/26 ,  C07C67/46 ,  C07C231/04 ,  C07C303/22 ,  C07C303/32 ,  C07C69/72 ,  C07C309/51

摘要： The invention relates to a method for the production of β-ketocarboxylic acid derivatives of formula (I) or the salts thereof, where X = NR', O or S, R, R', R1-R4 independently = H, alkyl, alkenyl, aryl or heteroaryl, by reaction of a diketene of formula (II) with a compound comprising an active hydrogen of formula ROH, NHRR' or RSH, characterised in that the reaction is continuously carried out in a microreactor.