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126 条记录 (耗时 0.021 秒)

    NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES
    6.
    发明公开
    NOVEL GREEN AND ORANGE FLUORESCENT LABELS AND THEIR USES 审中-公开
    奥古斯丁绿色荧光灯

    公开(公告)号：EP1546673A4

    公开(公告)日：2006-08-09

    申请号：EP03754878

    申请日：2003-09-23

    申请人： CHROMAGEN INC

    发明人： BHATT RAM ,  CONRAD MICHAEL J ,  BENCHEIKH AZZOUZ ,  XIONG YIFENG

    IPC分类号： G01N1/00 ,  C07C309/50 ,  C07C309/51 ,  C07C311/29 ,  C07C331/20 ,  C07D207/44 ,  C07D207/452 ,  C07D207/46 ,  G01N33/533

    CPC分类号： C07D207/46 ,  C07C309/50 ,  C07C309/51 ,  C07C311/29 ,  C07C331/20 ,  C07C2603/50 ,  C07D207/452 ,  G01N33/533 ,  Y10S436/80

    摘要： The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, the fluorescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.

    摘要翻译： 本发明提供了新颖的荧光化合物和共价附着化学物质，其有利于这些化合物用作低水平生物分子的超敏感和定量荧光检测的标签。 在优选的实施方案中，本发明的荧光标记是羟基芘三磺酸和二磺酸的新衍生物，其可用于目前使用放射​​性同位素，着色染料或其它荧光分子的任何测定中。 因此，例如，使用标记的抗体，蛋白质，寡核苷酸或脂质（包括荧光细胞分选，荧光显微术（包括暗视野显微镜），荧光偏振测定，配体，受体结合测定，受体活化测定和诊断测定） 使用本文公开的化合物。

    VERFAHREN ZUR BEHANDLUNG VON LÖSUNGSMITTELGESPONNENEN CELLULOSISCHEN FASERN
    8.
    发明公开
    VERFAHREN ZUR BEHANDLUNG VON LÖSUNGSMITTELGESPONNENEN CELLULOSISCHEN FASERN 有权
    了治疗溶剂编织纤维素纤维

    公开(公告)号：EP1440190A2

    公开(公告)日：2004-07-28

    申请号：EP02778982.5

    申请日：2002-10-30

    申请人： LENZING AKTIENGESELLSCHAFT

    发明人： RENFREW, Andrew Hunter Morris

    IPC分类号： D01F11/00

    CPC分类号： C07C309/51 ,  D01F2/00 ,  D01F11/02 ,  D06M13/41

    摘要： The invention relates to a method for treating solvent-spun cellulose fibers during which the fibers are brought into contact with a textile auxiliary in an alkaline medium. The inventive method is characterized in that a compound of general formula (I) or a salt thereof is used as the textile auxiliary, whereby: R1 is a binding link selected from the group consisting of a linear or branched chain with 1 to 4 C atoms and phenyl; R2 and R3 are identical or different from one another and are selected from the group consisting of (CH2)m-CH=CH2 with m ranging from 0 to 2, and; R4 represents an ionic group and/or a group that can be ionized in the alkaline medium.

    PHENYL DERIVATIVES USEFUL AS BLOCKERS OF CHLORIDE CHANNELS
    9.
    发明公开
    PHENYL DERIVATIVES USEFUL AS BLOCKERS OF CHLORIDE CHANNELS 失效
    苯基衍生物氯化物通道阻滞剂

    公开(公告)号：EP0910358A1

    公开(公告)日：1999-04-28

    申请号：EP97924020.0

    申请日：1997-05-26

    申请人： NEUROSEARCH A/S

    发明人： CHRISTOPHERSEN, Palle ,  PEDERSEN, Ove

    IPC分类号： A61K31 ,  A61P1 ,  A61P7 ,  A61P9 ,  A61P27 ,  A61P29 ,  A61P37 ,  C07C233 ,  C07C271 ,  C07C275 ,  C07C309 ,  C07C311 ,  C07C335

    CPC分类号： C07C233/55 ,  A61K31/155 ,  A61K31/17 ,  C07C271/58 ,  C07C275/40 ,  C07C309/51 ,  C07C311/08 ,  C07C311/21 ,  C07C311/47 ,  C07C311/60 ,  C07C335/22

    摘要： The present invention relates to a method for the treatment of a disorder or disease of a living animal body, including a human, which disorder or disease is responsive to the blockade of chloride channels, comprising administering to a living animal body in need thereof a therapeutically effective amount of a compound having formula (I) or a pharmaceutically acceptable salt thereof wherein R?2, R3, R4 and R5¿ are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or R?3 and R4 or R4 and R5¿ together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R?2, R3, R4 and R5¿ is as defined above; Y is -CO-, -CS-, -SO¿2?-, or -C(=N-R?8¿)-, wherein R8 is hydrogen, alkyl, or cyano; X is -NH-, -CH¿2?-NH-, -SO2-NH-, or -CH2-; Z is -NR?6¿-, -O-, -CH=CH-, -N=CH-, -CH=N-, or -NR6-CH2-, wherein R6 is hydrogen, or alkyl; R?11, R12, R13, R14 and R15¿ are each independently selected from hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro, amino, and aryl, aralkyl, arylamino, aryloxy, aryl-CO-, or heteroaryl, wherein the aryl or heteroaryl group may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, hydroxy, alkoxy, halogen, trifluoromethyl, trifluoromethoxy, cyano, nitro and amino; or one of R?11 and R12, R12 and R13, R13 and R14 or R14 and R15¿ together form a fused 4 to 7 membered carbocyclic ring which may be unsaturated, or partially or fully saturated while the other substituents R?11, R12, R13, R14 and R15¿ is as defined above.